Physiology: Blood Supply, Gas Exchange, Ventilation and Perfusion Flashcards

1
Q

What is the blood supply to the lungs?

A

Bronchial Circulation

Pulmonary Circulation

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2
Q

What is bronchial circulation? (3)

A

Nutritive
Supplied via bronchial arteries
Arising from the systemic circulation and supplies oxygenated blood to airway smooth muscle, nerves and tissue

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3
Q

What is the pulmonary circulation? (4)

A

Consists of L and R pulmonary arteries anf dense capillary network surrounding alveoli
Carries entire cardiac output from RV
High flow, low pressure
Returns oxygenated blood to the LA

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4
Q

What does A stand for in pressure?

A

Alveolar

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5
Q

What does a stand for in pressure?

A

Arterial Blood

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6
Q

What does v stand for in pressure?

A

Mixed venous blood

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7
Q

What are the factors of diffusion across the membrane? (5)

A

Directly proportional too PP gradient
Directly proportional to gas solubility
Directly proportional to available surface area
Inversly Proportional to thickness of membrane
Most rapid over short distances

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8
Q

What is the PP of oxygen and carbon dioxide in alveoli and systemic arterial blood?

A

PO2 - 100mmHg

PCO2 - 40mmHg

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9
Q

What is the PP pf O2 and CO2 in pulmonary arterial blood and tissues?

A

PO2 - 40mmHg

PCO2 - 46mmHg

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10
Q

How alveoli aid gas exchange?

A

They have a large surface area

Thin membrane wall

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11
Q

What happens to gas exchange in Emphysema?

A

Normal or Low PO2 in alveoli

Low PO2 in arterial blood

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12
Q

What happens to alveoli in emphysema?

A

Alveoli destroyed causing reduced surface area

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13
Q

What to alveoli in Fibrotic Lung Disease?

A

Thickened alveolar membrane

Loss of compliance reduces alveolar ventilation

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14
Q

What happens to the gas exchange in fibrotic lung disease?

A

PO2 in alveoli is normal or low

PO2 in arterial blood is low

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15
Q

What happens to alveoli in Pulmonary Oedema?

A

Interstitial fluid between alveoli and capillaries is increased increasing the distance

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16
Q

What happens to gas exchange in Pulmonary Oedemas?

A

PO2 in alveoli is normal

PO2 in arterial blood is low

17
Q

What happens to alveoli in asthma?

A

Increased airway resistance decreases airway ventilation

18
Q

What happens to gas exchange on asthma?

A

PO2 in alveoli is low

PO2 in arterial blood is low

19
Q

What is the relationship observed between blood flow and ventilation at the base of the lung?

A

Blood flow is higher than ventilation as arterial pressure exceeds alveolar pressure

Blood flow > ventilation

20
Q

What is compressed at the base of the lung?

A

The alveoli

21
Q

What is the relationship observed between blood flow and ventilation at the apex of the lung?

A

Blood flow is low as arterial pressure is less than alveolar pressure

Ventilation> Blood flow

22
Q

What is compressed at the apex of the lung?

A

Arterioles

23
Q

Where does the majority of mismatch between ventilation and perfusion take place in the lung?

A

Apex

24
Q

What is the definition of shunt?

A

passage of blood through poorly ventilated areas of the lungs

Ventilation < Perfusion

25
Q

What is Alveolar Dead Space?

A

Alveoli that are well ventilated but not perfused

Ventilation > Perfusion

26
Q

What does the pulmonary circulation do when a shunt occurs?

A

Constriction of arterioles surrounding poorly ventilated alveoli due to hypoxia

Broncho dilation of arterioles surrounding better ventilated alveoli

27
Q

What happens the pulmonary circulation when alveolar dead space occurs?

A

Increase in bronchial constriction due to the decrease in PCO2 and pulmonary vasodilation due to the increase in PO2

28
Q

What is anatomical dead space?

A

air in the conducting zones of the respiratory tract and therefore not taking part in gas exchange

29
Q

What is Physiological Dead Space?

A

Alveolar Dead Space + Anatomical Dead Space