Physiology 1.10 Flashcards
What is an excitatory post synaptic potential?
change in membrane potential towards an action potential (-50mV); Na+ moves in, K+ moves out
What is an inhibitory post synaptic potential?
change in membrane potential away from an action potential; Cl- moves in
How can an action potential occur if a single excitatory post synaptic potential only generates about 10 mV of change in membrane potential?
several synaptic potentials add together to cause an action potential; summation
What is temporal summation?
1 neuron, many potentials to cause action potential
What is spatial summation?
more than one neuron being fired to cause action potential
What is Lambert Eaton Syndrome?
-antibodies to voltage gated Ca2+ channels on presynaptic terminal
What is Botulinism Toxin?
-destroys SnRPs (NTs not released from synaptic vesicles)
What is Myasthenia Gravis?
-autoantibodies to the postsynaptic ACh receptors
What are the types of ion-gated channels?
- voltage
- ligand (ionotropic and metabotropic)
- mechanical
What is an ionotropic channel?
- local effects
- fast response
- multiple protien subunits
What is a metabotropic channel?
- GPCR
- wide away of effects
- slow reponse
- one protein which crosses membrane 7 times
Which types of receptors do most anti-cholinergic drugs act on?
muscarinic
What types of receptors do anesthetic drugs act on?
nicotinic
