Physio - GI Flashcards
SOURCE: I cells
CCK
SOURCE: G cells
Gastrin
SOURCE: M cells
Motilin
SOURCE: K cells
Glucose dependent insulinotropic peptide
TRIGGER: Oral glucose
Glucose dependent insulinotropic peptide
TRIGGER: CHON
Gastrin
TRIGGER: Fasting
Motilin
TRIGGER: All types (Main: Fatty acids)
CCK
TRIGGER: H+ in the duodenum
Secretin
Somatostatin
SOURCE: S cells
Secretin
ACTION: Activates interdigestive/migrating myoelectric complex
Motilin
ACTION: Stimulates Parietal cells (Fundus) to release HCl
Gastrin
ACTION: Inhibits HCl secretion
Glucose dependent insulinotropic peptide
ACTION: Bile secretion
CCK
ACTION: Growth of gastric mucosa
Gastrin
ACTION: Increases biliary and pancreatic HCO3-
Secretin
ACTION: Inhibits gastric emptying time (2)
Glucose dependent insulinotropic peptide
CCK
Two homologous GI hormones
CCK and Gastrin
Homologous to Glucagon
Secretin
ACTION: Inhibits pancreatic HCO3- and enzymes
Pancreatic polypeptide
SOURCE: Pancreas
Pancreatic polypeptide
SOURCE: L cells
Glucagon-Like Peptide 1
ACTION: Stimulates Insulin secretion
Glucagon-Like Peptide 1
ACTION: Inhibits ALL GI hormones
Somatostatin
ACTION: Inhibits H+ secretion
Somatostatin
SOURCE: Mast Cells
Histamine
ACTION: Increases H+ secretion
Histamine
ACTION: Potentiates Gastrin and Ach action
Histamine
ACTION: Ultimate GI tract smooth muscle relaxant
VIP (Vasoactive Intestinal Peptide)
ACTION: Stimulates gastrin release from G cells
GRP (Bombesin)
ACTION: Contracts LES, Pyloric sphincter, Ileocecal valve
Enkephalins
ACTION: Inhibits anorexigenic neurons
Ghrelin
SOURCE: Gastric cells
Ghrelin
ACTION: Releases Neuropeptide Y to increase appetite
Orexigenic neurons
ACTION: Release POMC to decrease appetite
Anorexigenic neurons
ACTION: Inhibits Ghrelin
Peptide YY
ACTION: Stimulates Anoxergenic neurons
Leptin
Insulin
GLP-1
Area of the brain where appetite/hunger center found
Lateral hypothalamic area
Area of the brain where Satiety enter is found
Ventromedial hypothalamus
Sends signals to satiety and hunger centers
Arcuate nucleus