Physio - cell physiology Flashcards
Tight intercellular junction
Desmosomes
Macula adherens
Bridge for sharing of small molecules between cells
Gap Junction
Barrier to movement of proteins across membranes
Tight Junction
Zonula Occludens
Increased surface area for contact
Zonula Adherens
Equilibrium potential of Calcium
+120
Equilibrium potential of Sodium
+65
Equilibrium potential of Potassium
-85
Equilibrium potential of Chloride
-85
Macroglia that forms the myelin in the PNS
Schwann cells
Macroglia that forms the myelin in the CNS
Oligodendrocytes
Tissue macrohpage that act as a scavanger, removing debris in the nervous system
Microglia
Astrocytes in the white matter
Fibrous astrocytes
Astrocytes in the gray matter
Protoplasmic astrocytes
Macroglia that send processes that envelop synapses and help form the BBB
Astrocytes
TTriggers REM sleep
Acetylcholine
Decreased levels in Huntington’s dementia and Alzheimer’s dementia
Acetylcholine
Neuromodulator in the CNS
Neurotransmitter in the PNS
Norepinephrine
Primary neurotransmitter from post ganglionic sympa neurons
Norepinephrine
Secreted in the substantia nigra
Dopamine
Found in the median raphe of the brain stem
Serotonin
Inhibitory neurotransmitter, vasodilator
Nitric Oxide
Relieves effects of bee sting by decreasing contraction of airway smooth muscles
Epinephrine
Greater beta 2 action than NE
Epinephrine
Halflife of NE
2 mins
Secreted by hypothalamus to inhibit prolactin
Dopamine
Low levels associated with depression
Serotonin
Main inhibitory neurotransmitter in the spinal cord
Glycine
Main inhibitory neurotransmitter in the brain
GABA
Main excitatory neurotransmitter in the brain
Glutamine
Inhibits neurons in the brain involved with pain perceltopm
Opiod peptides
Involved in fast pain
Glutamate
Involved in Slow pain
Substance P
GABA B receptor
Metabotropic or Ionotropic?
Metabotropic
GABA A receptor
Metabotropic or Ionotropic?
Ionotropic
NIcotine receptor
Metabotropic or Ionotropic?
Ionotropic
ANP receptor
Metabotropic or Ionotropic?
Ionotropic
Opioid receptors
Metabotropic or Ionotropic?
Metabotropic
Neurokinin receptor
Metabotropic or Ionotropic?
Metabotropic
5HT3 receptor
Metabotropic or Ionotropic?
Ionotropic
Glycine receptor
Metabotropic or Ionotropic?
Ionotropic
NMDA receptor
Metabotropic or Ionotropic?
Ionotropic
Enk > End and Dy
Kappa
Dyn»_space; End and Enk
Delta
End > Enk > Dy
Mu
[SARCOMERE]
Borders
Z line
[SARCOMERE]
Midline
M line
[SARCOMERE]
Myosin only
H band
[SARCOMERE]
Actin only
I band
[SARCOMERE]
No myosin heads
Bare Zone
[SARCOMERE]
Spans entire length of myosin
A band
Invaginations of the sarcolemma
T-tubules
Actuvates Ryanodine receptors (Ca channels)
DHPR
Spreads the action potential to all parts of the muscle
T-tubules
Protein that stores Ca in the SR
Calsequestrin
Pumps Ca from ICF to the SR
SERCA
Binds myosin to Z lines, binds Z lines to M line
Titin
Determines normal stiffness of the ventricular muscle
Titin
Largest protein in human body
Titin
Calcium release channel in the SR
Ryanodine
Stabilizes sarcolemma
Dystrophin
Binds Z lines to sarcolemma
Desmin
Molecular rulers that sets length of actin
Nebulin
Binds actin to Z lines
Actinin
CapZ Protein
Binds actin to beta dystroglycan in the sarcolemma
Dystrophin