Physical Pentration Enhancer Flashcards
Define the microneedls
Is a micron-sized needle with a hight of 10-2000 micro.m. and a width of 10-50 micro.m. , and are widely used in transdermal drug delivery system
What are the advantages of microneedles?
1 Safe
2 Painless
3 Convenient
4 Noninvasive
5 Efficient drug delivery
6 have the ability to improve patient compliance as it does not hurt the nerves.
7 improving the bioavilability of the drug via avoiding hepatic first pass metabolism.
What are the advantages and disadvantages of metal microneedl?
Advantages:
Mechanical strength and toughness
Disadvantages:
Breakage of the microneedles inside the skin may lead to safety problems
Give reason, metal material are widely used in transdermal system
Due to the mechanical strength and toughness
Metal material can be used to make ……… microneedl, …………… , and …………
1 solid microneedl
2 coated microneedl
3 hollow microneedl
What are the disadvantages of inorganic materials microneedls?
There is no biocompatibility and the breakage in the skin may leads to safty problems.
Inorganic materials are used to make …..
Coated microneedl
Hollow microneedl
Solid microneedl
Considered the most promising materials for microneedl fabrication
Polymer material
What are the materials that we can manufacturing the microneedl from?
1_ Polymer
2Metal
3 Inorganic
The polymer material used to making……..
Solid microneedls. Coated mocroneedls. Dissolving microneedls. Holow microneedls. Hydrogel containing microneedls.
What are the mode of action of solid microneedls?
The solid microneedl are penetrated into the skin, and then the drugs delivered through the channels hereby created.
What are the advantages and disadvantages of solid microneedls?
Advantages:
Drug deliverey process is safe.
Infection and toxic substances can be avoided, as the channels created by the microneedls close after the microneedls are removed.
Dusadvantages:
The brokage of solid microneedl may lead to safty problem.
Waht is the mechanism of coated microneedl?
The microneedl patch is inserted into the skin, then the drug coated on the microneedle tips released into the skin.
What is the michanism of dissolving microneedles?
These microneedles are manufactured from soluble polymers(poly-vinyl alcohol), which carry drugs and start dissolving several minutes after application to the skin until completely dissolve releasing the drug through the skin.
What is the michanism of Hollow microneedles?
These microneedles contain holes were drugs can be applied through these holes.
What are the hydrogel microneedl forming for?
Aqueous blends of poly(methylvinylether/maleic acid) and poly(ethylene glycol)
What is the michanism of hyrogel microneedle?
It contain no drug themselves, but swell in skin to allow diffusion of the drug contained in an attatched reservoir layer.
What are the iontophoresis composed of?
1_ Active electrode containing the drug.
2Inert electrode containing different ion.
3 Power supply.
Write a short note about iontophoresis.
Is a process of transdermal drug delivery by use of voltage gredient on the skin, molcules are transported across the stratum cornum by electrophoresis, the electrical field can increase the permiability of the skin.
What are the mechanism of Laser Ablation
Removing the stratum corneum barrier to enhancing topical drug delivery.
What are the mechanism of electroporation?
Creats transient aqueous pores in the lipid by application of high voltage of electrical pulses for milliseconds, these pores provide pathwayse for drug penetration
Write a short note about the phonophoresis.
Is the use of ultrasounds to enhance the delivery of tobically applied drugs.
Has been used in analegisics and anti-inflammatory agents
Phonophoresis
What are the iontophoresis?
Is a process of transdermal drug delivery by use of a voltage gradient on the skin. Molcules are transported across the stratum corneum by electrophoresis and electroosmosis, the electric field increase the permiability of the skin.
