Phys- Absorption Of Water And Electrolytes Flashcards

1
Q

The tight junctions in intestinal epithelial cells are most leaky where?

A

Duodenum- get progressively tighter as you move down the tract

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2
Q

What is the passage of ions and water through the tight junctions and lateral intracellular spaces called?

A

Paracellular transport

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3
Q

What is transport through the cells called?

A

Transcellular transport

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4
Q

What contributes more to ion conductance of the mucosa?

A. Paracellular transport
B. Transcellular transport

A

A. Paracellular transport

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5
Q

Little net H2O absorption occurs in the _____ but chyme is brought to _____ here.

A

Duodenum, isotonicity

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6
Q

Where does the most H2O absorption occur?

A

Jejunum

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7
Q

Where is sodium absorbed?

A

Along the ENTIRE length of the intestine

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8
Q

Where is the net rate of absorption of sodium the highest?

A

In the Jejunum

  • enhanced by presence of sugars and AAs
  • Na movement is providing the energy for sugar and AA transport
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9
Q

The colon normally pumps sodium ____ a large electrochemical gradient. What is this affected by?

A

Against

Affected by aldosterone

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10
Q

Chloride and bicarbonate are absorbed in large amounts where?

A

Jejunum

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11
Q

Most of the bicarbonate from pancreatic and liver secretions has been reabsorbed by the end of the _____.

A

Jejunum

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12
Q

In the ____ and ____, Cl continues to be _____ but HCO3- is normally _____. This si dude to a brush border exchange protein not found int he jejunum.

A

Ileum
Colon
Reabsorbed
Secreted

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13
Q

Net flux of potassium is from ____ to the ____ in the jejunum and ileum.

A

From lumen to blood

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14
Q

What may be absorbed or secreted in the colon depending on the luminal concentration?

A

Potassium (above or below 25 mM)

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15
Q

Calcium is ____ absorbed by all segments of the intestine, especially the ___ and _____.

A

Actively
Duodenum
Jejunum

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16
Q

Calcium absorption is stimulated by ____ and _____.

A

Vitamin D mainly

Parathyroid hormone to a lesser extent

17
Q

What binds calcium at the brush border membrane?

A

IMCal - intestinal membrane calcium-binding protein

18
Q

What binds two calcium ions and appears to be essential for calcium absorption?

A

Cytotoxic calcium-binding protein (CaBP or Calbindin)

19
Q

What is essential for normal calcium absorption and induces the synthesis of CaBP?

A

Vitamin D- also increases Ca-ATPase in the basolateral membrane

20
Q

Parasympathetic influence is to (increase/decrease) motility and tone of the stomach and intestine while the sympathetic influence is to (increase/decrease) through which receptor?

A

Increase- para

Decrease- sym, through alpha 2

21
Q

Parasympathetic influence on sphincter secretion is usually _____. Sympathetic is usually ____ with ___ receptor and ____ with ____ receptor.

A

Relaxation, can be stimulation

Contraction with alpha 1 and inhibition with alpha 2