Phosphodiesterase Inhibitors

Question 1

Action of PDEi’s

Answer 1

Increase Cardiac Output + Peripheral Resistane decreased

Question 2

Mechanism of Action of PDEi’s

Answer 2

Inhibit the PDE enzyme found on cardiac and vascular walls = raised cAMP levels

Raised contractility and pulmonary wedge pressure and peripheral resistance decreased w/out change in BP

Question 3

Administration of PDEi

Answer 3

Intravenous

Question 4

Types of PDEi

Answer 4

Enoximone

Milrinone

Question 5

Indications of PDEis

Answer 5

Severe acute HF refractory to other drugs

CCF with decreased filling and output

Question 6

Side Effects of PDEis

Answer 6

Nausea & Vomiting
Arrhythmias
Liver dysfunction
Abdominal Pain
Hypersensitivity