Phosphodiesterase Inhibitors Flashcards
Types of phosphodiesterase inhibitors
Non specific PDE inhibitors
PDE5, 4, 3 inhibitors
Platelets inhibitors
Non specific PDE inhibitors ?
Theophylline
Uses: Increase in camp - bronchodilation
S/e: cardio toxicity
Neurotoxicity
Abdominal pain
PDE-5 inhibitors
‘Fils - 5ills
Sidenafil
Increase in cGMP and increase of NO
Pulmonary Vasodilation
Smooth muscle relaxation
PDE-5 inhibitors use
- pulmonary HYPERTENSION
- BPH (tadalafil)
- erectile dysfunction (erection)
PDE-5 inhibitors s/e
Facial flushing Heart burn Hypotension Dyspepsia Headache
What is the unique s/e of tadalafil
Cyanopia due to inhibition of PDE-6 in the retina
PDE-4 inhibitors
Roflumilast - RO4lumilast
Increase in cAMP in neutrophils, bronchial epithelium, granulocytes
Use of rofulmilast
Severe copd
Side effects of of rofulmilast
Insomnia, abdominal pain, depression
, anxiety
PDE-3
MILRINONE
Works on vascular smooth muscle and cardiac via camp
Use of MILRINONE
Acute decompasated hf with cardiogenic shock
S/e of mirilone
Hypotension
Tachycardia
Arrhythmia
Platelets inhibitors
Cilostazol -also a pde3 inhibitor
Dipyridamole
They increase camp and inhibits platelets aggregation.
Use of platelets inhibitors
-intermittent claudation
Stroke and TIA prevention
Cardiac stress testing (only dipyridamole due to vasodilation)
Prevent coronary stent restenosis
Unique traits of dipyridamole
It leads to platelets inhibition and also parents uptake of adenosine so accumulation of extracellular adenosine that it causes vasodilation
Also a nonspecific PDE Inhibitor
