Cholinergic Antagonists - Drugs Flashcards
What are the types of cholinergic agonists
Muscarinic blockers
NMJ blockers
Examples of muscarinic blockers
Atropine Scopolamine Ipratropium Benztropine (and other tropines) Prienzepine
Procyclidine Trihexy phenidyl HCL Hyocine butylbromide Mebeverine Tolterodine Oxybutynin Darifenacin
What anti muscarinic drug has no atropine s/e
Mebeverine
What antispasmodic drug has no anti cholinergic effect
Drotaverine
Atropine is to —— as OPC is to ——
Hyperthermia
Hypothermia
Does atropine cross bbb
Yes and do causes CNS symptoms
What is the related effects of atropine to HR in terms of dose
At low dose- low HR
At high dose- High HR
Scopolamine
An antimuscarinic agent used for motion sickness
Has same effects as atropine and an added s/e of short term memory blockage.
What other muscarinblocker is used for motion sickness
Hyocine butylbromide in hospital but scopolamine is the DOC in exam
Muscarinic blockers that cross bbb
Atropine
Scopolamine
Location of M1, M2, M3
M1 - CNS and enteric nervous system Gq
M2 - heart Gi (atria, av node, sa node)
M3 - eye, glands, beta cell of pancreas, bronchi, and urinary bladder Gq
Ipratropium ?
Same as atropine
Doc for bronchial asthma and COPD
Used in acute excercabation of asthma along with B2 agonist
tiotropium is also used but has a longer duration.
Pirenzepine
Used in treatment of PUD as it acts of M1 to reduce gastric secretion
Which muscarinic blocker is used to treat tremor(acute dystonia) in Parkinson dx
Benztropine
Procyclidine
Trihexyphenidyl HCL
What anti muscarinic drugs are recognized for urinary urgency and bladder spasms after a urology surgery
Tolterodine
Oxybutynin
Darifenacin
What muscarinic blockers are promoted for urinary incontinece
FA- OXYBUTYNIN
Tolterodine
Darifenacin
What are the signs of anti cholinergic poisoning
CNS effects - headache restlessness ataxia, hallucinations
Hyperthermia
Speech and swallowing disturbances
Cardio acceleration, pupillary dilation
Antidote for atropine poisoning
Physostigmine
Sedate pt with benzodiazepines
Nicotinic/ganglion ice blockers are
Nicotine
Hexamethonium
Trimethaphan
Mecamylamine
Tx of Tourette syndrome
Mecamylamine
Also used in malignant HTN and for smoking cessation
Muscarinic antagonist that produces mydriasis and cycloplegia
- Atropine
- Homatropine
- tropicamide
Glycopyrrolate
Muscarinic antagonist
- reduce airway secretions preop
- reduce peptic ulcer, and drooling
Muscuranic antagonist for irritable bowl syndrome?
Hyoscyamine
Dicyclomine
They are antispasmodic
Muscarinic antagonist for overactive bladder
SOFT
S- solifenacin
O- Oxybutynin
F- flavoxate
T- Tolterodine
Major side effects of atropine?
- hyperthermia in infants : low sweat
- acute angle closure glaucoma in elderly: mydriasis
- urinary retention in BPH men
- cycloplegia
- tachycardia
- dry flushed skin
- disorientation
