Ingested Seafood Toxins

Question 1

What are the toxins produced by sea food that causes reactions

Answer 1

• histamine: histamine release
• Tetrodotoxin: closure of sodium channels
• Ciguatoxin: opening of sodium channels

Question 2

What is the source of histamine sea food poisoning

Answer 2

Dark meat fish such as- tuna, mahi-mahi, mackerel, bonito

Question 3

What is the Moa of histamine sea food poisoning

Answer 3

It contains histamine decarboxylase that converts histidine to histamine

Question 4

What are the symptoms of histamine sea food poisoning

Answer 4

• itching, erythema , oral burning sensation, urticaria, facial flushing, can lead to bronchospasm, hypotension and angioedema

Question 5

What is the treatment of scombroid poisoning

Answer 5

• antihistamine
• albuterol
• epinephrine (+-)

Question 6

What is the source of tetrodotoxin

Answer 6

Puffer fish

Question 7

What is the moa of tetrodotoxin poisoning

Answer 7

It binds to fast voltage gated Na channels and leads to their closure and no depolarization

Question 8

What are symptoms of tetrodotoxin

Answer 8

Nausea, diarrhea, parasthesias, weakness, dizziness, loss of reflexs

Question 9

Treatment of tetrodotoxin

Answer 9

Supportive

Question 10

Source of Ciguatoxin poisoning

Answer 10

Reef fish: braccuda, moray ell, snapper

Question 11

Mechanism of action of Ciguatoxin poisoning

Answer 11

Opening of Na2+ channels causing depolarization

Question 12

Symptoms of Ciguatoxin poisoning

Answer 12

Nausea vomiting diarrhea reversal of hot and cold sensation bradycardia heart block and hypotension

Question 13

Treatment of Ciguatoxin poisoning

Answer 13

Supportive