Phosphate Binders

Question 1

Calcium carbonate (tums) dose:

Answer 1

500mg 3X daily with meals

do not exceed 1500mg/d elemental calcium

Question 2

Calcium acetate (PhosLo)

Answer 2

2-3 tablets 3X daily with meals
do not exceed 1500mg/d elemental calcium
(169mg/tablet)

Question 3

calcium acetate compared to calcium carbonate

Answer 3

calcium acetate will bind twice as much phosphate compared to calcium carbonate
may produce few hypercalcemic events

Question 4

Sevelamer carbonate (Renvela) dose:

Answer 4

phose>5.5-=7.5mg/dL 1600mg 3X daily

Question 5

Sevelamer carbonate (Renvela) adverse effects

Answer 5

GI upset, nausea, vomiting, diarrhea
(decreased LDL by 15-30%
decreased uric acid, good for Gout)

Question 6

Lanthanum carbonate (Fosrenol) dose:

Answer 6

250-750mg 3X daily with meals
(chew tab 500, 750, 1000mg)
may titrate to 1500-300mg per day

Question 7

Lanthanum carbonate (Fosrenol) adverse effects

Answer 7

GI, nausea, vomiting, diarrhea

Question 8

Sucroferric oxyhydroxide (Velphoro) dose:

Answer 8

on dialysis

500mg chewable tablet 3X daily with meals

Question 9

Sucroferric oxyhydroxide (Velphoro) adverse effects

Answer 9

darkened stools
GI
DO NOT give with levothyroxine or paricalcitrol

Question 10

Auryxia (ferric citrate) dose

Answer 10

2 tablets 3X daily with meals

each tablet 1g ferric citrate

Question 11

Auryxia (ferric citrate) adverse effects

Answer 11

discolored feces

GI