Dosage exam 3

Question 1

Lupron

Answer 1

erosion-controlled system
leuprolide acetate/PLA
advanced prostate cancer

Question 2

Zoladex

Answer 2

erosion-controlled system
foserelin acetate/PLGA
prostate cancer, breast cancer, endometriosis

Question 3

Nutropin

Answer 3

erosion-controlled system
human growth hormone/PLGA
growth hormone deficiency

Question 4

Gliadel Wafer

Answer 4

erosion-controlled system
BCNU/polyanhydride
high-grade malignant flioma

Question 5

Oros tablet

Answer 5

Osmotic system
Release due to osmotic pressure difference and
diffusion

Question 6

Benzocaine

Answer 6

topical effects deep tissue: local anesthetics

Question 7

hydroquinone

Answer 7

topical effects deep tissue: lighten excessively pigmented skin

Question 8

5-fluorouracil

Answer 8

topical effects deep tissue: skin-cancer

Question 9

aluminum chloride

Answer 9

topical action on skin glands: antiperspirant

Question 10

retinoids

Answer 10

topical, reset processes of epidermal proliferation and differentiation

Question 11

petrolatum

polyethylene dissolved in mineral oil (Plastibase)

Answer 11

ointment, hydrocarbon base

Question 12

polydimethylsiloxane oil

Answer 12

ointment, silicone base

Question 13

ointment containing W/O emulsifiers, aqueous solution of a drug

Answer 13

ointment, absorption bases

Question 14

polyethylene glycol ointment

Answer 14

ointment, water soluble bases

Question 15

tragacanth

Answer 15

polymer for gel

Question 16

pectin

Answer 16

polymer for gel

Question 17

carrageenan

Answer 17

polymer for gel

Question 18

methylcellulose

Answer 18

polymer for gel

Question 19

carboxymethylcellulose

Answer 19

polymer for gel

Question 20

carbopol

Answer 20

polymer for gel

Question 21

ascorbate

Answer 21

enhancer for topical transdermal, reducing agent, disrupt disulfide bonds of proteins in keratinized cells

Question 22

dithiothreitol

Answer 22

enhancer for topical transdermal, reducing agent, disrupt disulfide bonds of proteins in keratinized cells

Question 23

azone (laurocapram)

Answer 23

enhancer for topical transdermal, nonpolar, oily liquid, fluidize intracellular lipid lamella region of stratum corneum
(makes paracellular space bigger)

Question 24

diemthyl sulfoxide (DMSO)

Answer 24

dipolar solvent, enter aqueous region of stratum corneum, interact with lipid polar heads to expand hydrophilic region between polar heads

Question 25

polyvinylpyrrolidone (PVP)

Answer 25

polymer used to make microneedles, water soluble