Pharmokinetics APEX Flashcards
1
Q
A
2
Q
A
3
Q
A
4
Q
A
5
Q
A
6
Q
A
7
Q
What is context sensitive half life??
A
8
Q
A
9
Q
A
10
Q
A
11
Q
A
12
Q
Ionized vs Non-ionized:
Solubility?
Pharmacologic effect?
Hepatic biotransformation?
Renal elimination?
Diffusion across lipid bilayer??
A
13
Q
A
14
Q
A
15
Q
A
16
Q
A
17
Q
A
18
Q
a1-glyco increase (5)
Surgery ____
Heart____
Chronic ___
Age____
_____
and decrease factor?
A
19
Q
What conditions increase alpha 1-acid glycoprotein
What decreases alpha 1-acid glycoprotein?
A
20
Q
A
21
Q
A
21
Q
A
22
Q
Examples of the drugs:
A, P, W, H, T
A
23
Q
A
24
Q
(3) Acid?
____
____ group
A
25
Q
A
26
Q
What is extraction ratio?
ER of 1.0 means?
ER of 0.5 means?
Extraction ratio formula?
A
27
Q
Drug examples??
Induction drugs?
BB? (3)
CCB(3)
A
High perfusion dependent:
Fent/morphine/sufent, meperidine,
naloxone
ketamine, prop, lido,
bup,
metoprolol, pronalol, alprenolol,
nifedipine, diltiazem, verapamil
28
Q
A
29
Q
A
30
Q
A
31
Q
A
32
Q
A
33
Q
A
34
Q
A
35
Q
A
36
Q
A
37
Q
A
38
Q
A
39
Q
A
40
Q
A
41
Q
A
