Pharmokinetics APEX Flashcards
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What is context sensitive half life??
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12
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Ionized vs Non-ionized:
Solubility?
Pharmacologic effect?
Hepatic biotransformation?
Renal elimination?
Diffusion across lipid bilayer??
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a1-glyco increase (5)
Surgery ____
Heart____
Chronic ___
Age____
_____
and decrease factor?
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19
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What conditions increase alpha 1-acid glycoprotein
What decreases alpha 1-acid glycoprotein?
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22
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Examples of the drugs:
A, P, W, H, T
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(3) Acid?
____
____ group
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What is extraction ratio?
ER of 1.0 means?
ER of 0.5 means?
Extraction ratio formula?
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Drug examples??
Induction drugs?
BB? (3)
CCB(3)
High perfusion dependent:
Fent/morphine/sufent, meperidine,
naloxone
ketamine, prop, lido,
bup,
metoprolol, pronalol, alprenolol,
nifedipine, diltiazem, verapamil
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