Opioids

Question 1

Answer 1

Question 2

Answer 2

Question 3

Process of pain transmission:

First order neuron
Second order neuron
Third order neuron

Answer 3

Question 4

Pain Modulation

Important site of modulation: ______

Inhibition pain occurs when (2):

Pain augmented by: (2)

Answer 4

Question 5

MOA of opioids:

Type of receptor?

What 2 electrolytes affected?

Answer 5

There are four types of opioid receptors
1.) Mu (MOP)
2.) Delta (DOP)
3.) Kappa (KOP)
4.) ORL1 (NOP)

Question 6

Pre-cursors for endogenous opioids:

Endorpins?
Enkephalins?
Dynorpins?

Also what receptors do each of those affect?

Answer 6

Question 7

Mu 1?

Analgesia where?
HR?
Mental?
Abuse?
Eyes?
Temp?
Urine?

Answer 7

Question 8

Compare Mu-1, Mu-2, Mu-3

Answer 8

Question 9

Mu 2?

Analgesia where?
HR?
Mental?
Abuse?
Eyes?
Temp?
Urine? Bowels?

Answer 9

Question 10

Kappa stimulation effects??
A, D,D,D,H

Answer 10

Question 10

Mu 3

Answer 10

Question 10

Opioid affect on

HR:
BP:
Myocardial function?

Answer 10

Question 11

How do opioids affect ventilation?

Answer 11

Question 12

How does opioid affect pupil?

What nerve?

Answer 12

Question 13

How does opioid affect nausea?

Where does it affect? (2)

Answer 13

Question 14

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Question 15

How does opioid contribute to urine retention??

_____ relaxation
_____ contraction

Answer 15

Question 16

How does opioids affect immune?

Answer 16

Question 17

Question 18

7

Answer 18

Question 19

Question 20

Which opioids have active metabolite? (2)

Which one doesnt?

Answer 20

Question 21

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Question 22

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Question 23

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Question 23

Name some MAO inhibitors that can cause serotonin syndrome?

Answer 23

Question 24

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Question 25

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Question 26

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Question 27

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Question 28

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Question 29

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Question 30

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Question 31

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Question 32

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Question 33

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Question 34

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Question 35

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Question 36

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Question 37

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Question 38

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Question 39

women vs men with morphine

Answer 39

In women, morphine is associated with a:
* Greater analgesic potency
* Slower onset of action
* Longer duration of action
* Lower post-operative opioid consumption