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Pharm II > PharmII_Exam1_pract > Flashcards

PharmII_Exam1_pract Flashcards

1
Q

What is the drug of choice for gas gangrene?

A

Penicillin G

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2
Q

What do PCNs combine with and inactivate?

A

Transpeptidase

A PCN binding protein

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3
Q

Are PCNs bacteriostatic or bactericidal?

A

Bacteriocidal

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4
Q

What simultaneous administration prolongs duration of PCN?

A

Probenecid

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5
Q

99% of PCN G and V are eliminated via where?

A

Kidney

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6
Q

Which antistaph PCN has poor oral adsorption?

A

Methicillin

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7
Q

What is the drug of choice for Listeria?

A

Ampicillin

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8
Q

Which drug is employed prophylactically by patients with abnormal heart valves, who are to undergo oral surgery?

A

Amoxicillin

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9
Q

Are ampicillin and amoxicillin resistant to penicillinase?

A

No

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10
Q

Which 3 drugs are effective against indole-positive proteus?

A

Carbenicillin
Ticarcillin
Piperacillin

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11
Q

What antipseudomonal drug can cause platelet dysfunction?

A

Piperacillin

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12
Q

Name the most potent ureido-penicillin?

A

Piperacillin

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13
Q

How does penicillin penetrate CSF?

A

Only with inflammation

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14
Q

The highest incidence of hypersensitivity to PCN occurs with which?

A

Ampicillin

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15
Q

Are cephalosporins effective against penicillinase producing bacteria?

A

Yes.

Due to increase in resistance

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16
Q

What class of antimicrobials are drug of choice for Klebsiella?

A

Cephalosporin

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17
Q

What are 1st gen cephalosporins active against?

A

PEcK
Proteus
E. coli
Klebsiella

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18
Q

Name the alternative to anti-staph PCN in penicillin allergic patients?

A

Cefazolin

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19
Q

Name the drug of choice in surgical prophylaxis?

A

Cefazolin

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20
Q

What are 2nd generation cephalosporins active against?

A

HEN PEcK

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21
Q

Name the 1st line of drugs for N. Gonorrheae?

A

Ceftriaxone - IV

Cefixime-oral

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22
Q

Name the cephalosporins that are useful against P. aerugionsa?
What generation

A

Ceftazidime
Cefoperazone
3rd generation

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23
Q

What are Cetizoxime and Moxalactam active against?

A

Bacteroides fragilis

3rd gen staph

24
Q

Name two cephalosporins that are excreted through the biliary tract?

A

Cefoperazone

Ceftriaxone

25
Q

What cephalosporin group are used to treat meningitis?

A

3rd generation

26
Q

Which drug is active against MRSA?

A

Vancomycin

27
Q

Which beta lactam antibiotic has the broadest spectrum and what is it used for?

A

Imipenem/cilastatin

Used in empiric therapy.

28
Q

How is bacitracin administered?

Why?

A

Look up

29
Q

What drug is used for corneal ulcers and external otitis?

A

Polymyxin B

30
Q

What is Polymyxin restricted to treating?

A

Gram - bacteria.

31
Q

Is polymyxin Bacteriostatic or bacteriocidal?

A

Bacteriocidal

32
Q

What is cycloserine mainly used for?

A

TB

33
Q

Which beta lactam is used in umbrella therapy?

A

Imipenem

34
Q

What is the MOA of beta lactams?

A

Inhibit cell wall synthesis

35
Q

Which antibiotic is highly active against Treponema pallidum(syphilis)?

A

PCN

36
Q

Name two beta lactams that are not excreted via the kidney?

A

Cefoperazone and Ceftriaxone

37
Q

Which drug is it safe to treat UTI in prego chicks?

A

Fosfomycin

one dose

38
Q

Increased resistance to hydrolysis of chromosomal beta lactamse is specific to what generation cephalosporin?

A

4th generation

39
Q

Which drug is used in carriers of meningococcal infxns?

A

Minocycline

40
Q

What is effective against ROcky Mountain Spotted Fever(Ricksettia)?

A

All tetracyclines

Chloramphenicol

41
Q

Which of the following is the most imp mech of resistance to tetracyclines?

A

Reduced permeability or increased efflux by an active transport protein pump.

42
Q

What is the tetracycline of choice for SIADH?

A

Demeciocycline

43
Q

What is the tetracycline of choice in renal insufficiency?

A

Doxycycline (excreted via bile).

44
Q

A skin rash is a type of what……..

A

Hypersensitivity rxn

45
Q

Which drug is resistant to staphy beta-lactamases?

A

Oxacillin

46
Q

Which group of drugs are Effective against pseudomonas aeruginosa (gram neg)

A 
Carbenicillin,
Ticarcillin,
Azlocillin, 
Piperacillin,
Mezlocillin
47
Q

Which drug is eliminated in the bile?

A

Nafcillin

good for renal dysfunction patients

48
Q

Which is the drug of choice for bacterial meningitis?

A

Ceftriaxone

49
Q

Does Probenecide help with NAfcillin?

A

NO!!! Bcaz Nafcillin is eliminated in the bile.

50
Q

Which drug is used for empiric therapy?

A

Impenem

51
Q

MOA of monobactam?

A

Inhibits bacterial cell wall synthesis

52
Q

Trt for respiratory tract infections?

A

Aztreonam

This is the only monobactem

53
Q

Vancomycin is given slowly through IV to treat what condition?

A

Endocarditis

54
Q

What is the name of the structure on the test?

A

Cephalospoprin

55
Q

What is used to treat Pseudomonas causing corneal ulcers?

A

Polymyxin B

56
Q

What is used to treat atypical pneumonia caused by Mycoplasm?

A

Doxycycline

57
Q

What is an AE of flucytosine?

A

Reverse bone marrow suppression

Pharm II (7 decks)

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