Pharmacy Flashcards
What are prescription drugs?
- Require to be written by an ACREDITED PRESCRIBER PROVIDER
- Legal document that contains info required to dispense
- CHCS, hand written scripts only, NO FAX’d prescriptions
** What is the DOD form to prescribe meds? **
DD 1289
- Used for all controlled drugs, unless directed by CO or Higher Authority
What is the POLY-prescription form?
NAVMED 6710/6
** What are all of the ways providers can submit prescriptions? **
CHCS
DD 1289
NAVMED 6710/6
** What information must be written in ink, indelible pencil, or typewritten on prescriptions? **
- Pt’s full name
- Date script was written
- Patient’s DOB
- Full drug name, form of drug, dosage size/strength in METRIC, quantity dispensed, and written generically
- Directions for PT
- Legible signature of provider
- refill authorization
How can IDC’s give meds without the DD 1289/NAVMED6710/6?
Proper SOAP Note documentation including drug administered
What are the General Principles of Pharm?
(1) The factors that affect the actions of drugs.
(2) Factors that affect drug reactions.
(3) Various types of drug interactions.
(4) Factors influencing drug response interactions.
What is Pharmacokinetic?
- Activities of drugs after it enters the body
- study of drug absorption, distribution, metabolism, and excretion
- fundamental concept: drug clearance, elimination of drugs from the body
What are the different types of drug absorption in the body?
- Active Absorption
- Passive Absorption
- Pinocytosis
- Bioavailability
What is active absorption?
Carrier Molecule such as a protein or enzyme activity moves the drug across the membrane
What is passive absorption?
Diffuse across membrane from area of higher concentration to area of lower concentration
- Water Soluble Drugs
What is Pinocytosis?
- Cells engulf the drug particle across cell membrane
- Pacman
What are the factors that alter BIOAVAILABILITY?
- drug form (tabletm capsule, sustained release, liquid, trans-dermal, patch, inhalation, etc.)
- route
- changes in liver metabolism caused by dysfunction
- GI Mucosa and motility
- food and drugs
- solubility: I.E. fat soluble are absorbed faster than water soluble
** What is bioavailability? **
- subcategory of absorption
- percentage of drug dose that reaches systemic circulation
- oral meds are only usable when metabolized/absorbed by liver
- Oral meds have 20-40% bioavailability
- IV meds have 100% bioavailability
How does distribution of drugs in the body work?
Movement of a drug throughout the body typically by proteins known as ALBUMIN
Where does metabolism of drugs happen?
Liver kidneys lungs plasma intestinal mucosa
WHat is excretion?
Elimination of drugs from the body
- kidneys excrete inactive compounds through urine
What is half-life?
- Time required for the body to eliminate 50% of the drug
- organ disfunction/ age, disease can increase risks of toxicity
WHat is Pharmacodynamics?
Drugs actions and effects within the body
- primary = desired effect
- secondary (side effects) = desired/undesired
Psychological dependence?
Compulsion to use substance to obtain a pleasurable experience
Pharmacogenetic disorder?
genetically determined abnormal response to normal dose of a drug
receptor?
specialized macromolecule that binds to the drug molecule, altering function of the cell and producing the therapeutic response
What are the alterations in Cellular Environment?
A drug that alters cellylar function can INCREASE OR DECREASE the PSYCHOLOGIC Functions of the cell
- Example: Increased HR - Decreased BP
Therapeutic Response - Alteration of cell to achieve desires response
Agonist: Drug that binds with receptor to produce therapeutic response
** What is an Antagonist? **
Drug binds to receptor stronger than agonist thus producing pharmacologic effect
- Narcan is antagonist to morphine