Pharmacology: SGLT2 inhibitors & Uricosuric agents Flashcards
1
Q
describe the role of SGLT1 and 2
A
they are responsible for reabsorption of glucose, SGLT1 in intestine + kidneys, SGLT2 just in kidneys
2
Q
give some examples of SGLT2 inhibitors
A
canagliflozin, dapagliflozin
3
Q
what are the effects of SGLT2 inhibitors
A
excretion of glucose, decrease HbA1c, weight loss
4
Q
what is the most commonly associated side effect of SGLT2 inhibitors
A
increased incidence genital bacteria and fungal infections
5
Q
give 2 examples of uricosuric agents
A
probenecid and sulfinpyrazole
6
Q
describe the action of uricosuric agents
A
the block the reabsorption of urate in the proximal tubule
7
Q
in what disease can uricosuric agents be a useful treatment
A
gout
