Pharmacology: Diuretics

Question 1

describe the general action of diuretics

Answer 1

increase urine outflow, normally by inhibiting the reabsorption of electrolytes at various sites in the nephron

Question 2

describe the general use of diuretics

Answer 2

used to enhance excretion of salt and water in conditions where an increase in the volume of ECF (ie oedema) causes tissue swelling

Question 3

what is the site of action of thiazide, loop and K sparing diuretics , and what does this mean

Answer 3

the apical membrane of tubular cells, hence if hydrophilic must enter the filtrate to act

Question 4

how do diuretics enter the filtrate

Answer 4

glomerular filtration or secretion via 2 important transport processes in the proximal tubule

Question 5

what are the 2 secretion transport processes by which diuretics can enter the filtrate

Answer 5

organic anion transporters(OAT)

or organic cation transporter(OCT)

Question 6

what affect does secretion of diuretics into the filtrate have on conc.

Answer 6

results in the conc. of the diuretic in the filtrate being higher than in the blood