Pharmacology risk factors CC

Question 1

Fentanyl-induced chest wall rigidity

Answer 1

• Extremes of age
• Concurrent use of medications that alter dopamine levels
• Higher doses or rapidity of injection

Question 2

Factors that make a drug less dialyzable

Answer 2

• Larger molecular weight (smaller molecular weight substances will pass through the membrane more easily than larger size molecules)
• Drugs with high protein binding (Drugs with high protein binding (>80%) will have small plasma concentrations of unbound drug available for removal)
• Drugs with a large volume of distribution (drug with a large volume of distribution is distributed widely through the tissue with low amounts of drug available in the plasma for removal)

MCQS

Question 3

Risk factors for propofol infusion syndrome (PRIS)

Answer 3

• Steroid use
• Vasopressors
• Low carbohydrate intake
• Poor tissue perfusion
• Sepsis
• Cerebral injury
• Younger age
• Errors of mitochondrial fatty oxidation

MCQs

Question 4

Risk factors for developing prolonged neuromuscular blockade following discontinuation of paralytic agent

Answer 4

• Depth of blockade
• Coadministration of steroids
• Hypomagnesemia and hypermagnesemia
• Renal failure
• Female sex