Pharmacology causes CC Flashcards
Drugs that cause lactic acidosis
- Propofol
- Metformin
- NRTIs
- Salicylates
- Propylene glycol
- Isoniazid
- Linezolid
Precipitation of serotonin syndrome
- Selective serotonin reuptake inhibitors
- Serotonin-norepinephrine reuptake inhibitors
- Monoamine oxidase inhibitors (Linezolid)
- Tricyclic antidepressants
- Tramadol, fentanyl
- 5-HT3 receptor antagonists (ondansetron)
- Triptans (sumatriptan)
Precipitators of neuroleptic malignant syndrome
- Typical (first-generation) antipsychotics: e.g. Haloperidol
- Atypical (second-generation) antipsychotics: e.g. olanzapine and aripiprazole
- Antiemetic drugs
- Withdrawal of antiparkinsonian medications
Opioid agonists that can be used for managing opioid withdrawal
- Methadone
- Buprenorphine.
Antibiotics not crossing the blood brain barrier
- Aminoglycosides
- Erythromycin
- Tetracyclines
- Clindamycin
- First-generation cephalosporins (e.g., cefazolin)
Common ICU drugs contraindicated with the use of NNRTI
- Midazolam
- Triazolam
Common ICU drugs contraindicated with protease inhibitors
midazolam,
triazolam,
amiodarone,
PPIs (with atazanavir),
histamine-2 blockers,
propafenone,
quinidine.
Commonly used ICU medications that are mixed in propylene glycol
- Lorazepam (Ativan)
- Diazepam (Valium)
- Phenytoin
- Phenobarbital
Propylene glycol is metabolized into lactic acid. Lactic acid produces metabolic acidosis.
Antimicrobials that are well absorbed by the gut
- Metronidazole
- Ciprofloxacin
- Rifampicin
- Clindamycin
- Linezolid
- Doxycycline
- Fluconazole
Non-depolarizing muscle relaxants with long onset of action
- atracurium,
- vecuronium,
- pancuronium
These agents have long onset of action, which making them less suitable for RSI.
