Pharmacology of Heart Failure Drugs Flashcards
which four classes of drugs can be used to treat heart failure?
- vasodilator drugs
- positive inotropes
- ACE inhibitors
- Diuretics
what is the role of positive inotropes?
it prevents the reduction of cardiac output caused by heart failure (i.e. increases stroke volume hence reducing left ventricular end diastolic pressure)
what is the role of ACE inhibitors?
prevents the formation of angiotensin 2 hence preventing water and sodium ions retention and other factors
what is the role of diuretics?
prevents water and sodium ions retention
-reduces pulmonary congestion but doesn’t increase stroke volume
what is the role of vasodilator drugs?
- prevents rise in preload on the heart
- prevents rise in central venous pressure
- prevents rise in afterload
- stimulates tissue perfusion (passage of blood and fluids through a vessel/channel)
what two things would work best when combined to improve heart failure?
combining vasodilators and inotropic therapy
What is the effect of inotropic drugs?
improves the cardiac performance so the stroke volume (cardiac output) increases
how do inotropic drugs work?
by putting calcium back into the heart muscles causing a more forceful contraction
What is the role of calcium in muscle contraction?
- calcium enters via voltage-gated calcium channels and stimulates the release of calcium from the sarcoplasmic reticulum into the cytosol
- this switches on the contractile machinery (myosin and actin contraction causing heart muscle contraction)
where must calcium be for it to be used for muscle contraction?
in the cytosol
where does calcium come from?
- from outside the cell and enters via the voltage-gated calcium channels - this triggers a calcium induced calcium release
where is calcium stored?
from the sarcoplasmic reticulum
what is the mechanism of action of adrenergic agonists on muscle contraction?
- b1-agonists bind to b1-adrenergic receptors in the cardiac myocyte
- this receptor is coupled to a G-protein.
- this causes a mechanism associated with adenylyl cyclase
- ATP is therefore converted to cAMP
- cAMP activates PKA to phosphorylate calcium channels forcing them open.
give an example of an inotrope?
adrenergic agonists
when would you use adrenergic agonists?
in an emergency e.g. cardiogenic shock
-because they’re short term and have a short half life and are rapid working
what are risks with adrenergic agonists?
- can cause arrhythmia
- can cause myocardial oxygen demand
what is the mechanism of action of cardiac glycosides on muscle contraction?
- useful for atrial fibrillation and heart failure and antiarrythmia
- don’t have a direct action on calcium channels unlike b1-agonists
- slows down conduction from AV node
- works to block Na+/K+ ATPase pump
- this slows down Na+ pumping out of the cell causing a build up on Na+ inside the cell
- The Na+/Ca2+ exchanger usually pumps Ca2+ out of the cell and Na+ in but it won’t be able to do so as there will be no Na+ conc gradient when
- Therefore no pumping of Ca2+ out of the cell will stop more Ca2+ coming in
- calcium is also then stored into the sarcoplasmic reticulum. This causes rise for more Ca2+ to be able to be released from the sarcoplasmic reticulum, hence a more forceful contraction.
how does Na+/K+ ATPase work?
pumps 3Na+ out of the cell in exchange for 2K+ into the cell