Pharmacology of Anticoagulants

Question 1

What is Warfarin used for?

Answer 1

Venous Thrombosis, Pulmonary Embolism, Systemic Embolism

Question 2

Adverse effect of warfarin?

Answer 2

Purple toe syndrome; Metabolized by CYP2C9

Question 3

What is the MOA of Dabigatran?

Answer 3

Prodrug that competitively inhibits thrombin

Question 4

Uses Dabigatran?

Answer 4

Reduces stroke and systemic embolism in patients with AF.

Idarucizumab is the antidote.

Question 5

MOA of unfractioned heparin

Answer 5

Binds allosterically to antithrombin to inhibit F10 and thrombin.

Question 6

Use of unfractioned heparin? Adverse effect?

Answer 6

Acute MI, Unstable angina, DVT; Can cause HIT

Question 7

What is different about Low molecular weight heparin as opposed to unfractioned heparin?

Answer 7

It has a greater effect on F10 than thrombin; Can be given subQ

Question 8

Use of protamine sulfate?

Answer 8

Antidote for heparin

Question 9

Whats the difference between Fondaprinux and heparin?

Answer 9

Fondaprinux can be used in HIT

Question 10

MOA of Bivalirudin?

Answer 10

Direct inhibitor of thrombin; Can be used in HIT