Hemostasis Disorders

Question 1

Which plasma procoagulants are made in the liver?

Answer 1

All except for F8

Question 2

Which plasma procoagulants depend on Vitamin K?

Answer 2

F2, 7, 9 and 10

Question 3

What is the intrinsic pathway?

Answer 3

F12, 11, 9, 8, 5, 10, Plasminogen, Fibrinogen, 13

Question 4

What is the extrinsic pathway?

Answer 4

F7, 5, 10, Plasminogen, Fibrinogen, 13

Question 5

Which test measures the intrinsic pathway? Extrinsic pathway?

Answer 5

PTT detects abnormalities prior to F 10, PT

Question 6

What will give an abnormal Prothrombin time?

Answer 6

Deficiencies of F1, 2, 5, 7, and 10.

Heparin activated antithrombin 3.

Question 7

What will give an abnomal Thrombin Clotting time?

Answer 7

Fibrin degradation products, Antithrombin-heparin cofactor

Question 8

What is Fibrin degradation products?

Answer 8

A test of the fibrinolytic system; Plasmin attacks fibrin-fibrinogen = FDP

Question 9

What can cause a Vitamin K deficiency?

Answer 9

Diet, Lack of bile salts (obstructive jaundice, fistula), Intestinal malabsorption w/ decreased gut flora (antibiotics)

Question 10

What is the MOA of Coumarin/Warfarin?

Answer 10

Antagonizes Vitamin K; Overdose characterized by bleeding and abnormal PT, PTT.

Question 11

What is the MOA of Heparin?

Answer 11

Binds to antithrombin 3 to inactivate thrombin. Overdose therapy is protamine sulfate. Prolonged PT, PTT.