Oncogenesis Flashcards
1
Q
What are the hallmarks of cancer?
A
- Self-sufficiency in growth signals
- Insensitivity to anti-growth signals
- Limitless reproduction
- Evading apoptosis
- Tissue invasion and metastasis
2
Q
Differentiate Oncogenes from Tumor Suppressor genes
A
Oncogenes: Genes promoting cellular growth
Tumor supressor: Genes inhibiting excessive growth.
3
Q
Important facts about cancer incidence
A
- Incidence starts around 30.
2. Palpable cancer means there are a lot of cells
4
Q
Important facts learned from the models of Human Cancer
A
- Its the pathway change thats important.
2. Carcinogenesis is a multi-step process
5
Q
What are the symptoms of CML?
A
Fatigue, night sweats and high blast counts.
6
Q
What is the pathogenesis of the Philadelphia Translocation?
A
BCL is a highly transcribed gene, but when the translocation causes increased ABL expression, it causes an oncogenic mechanism.
7
Q
How is CML treated?
A
Gleevec, a tyrosine kinase inhibitor that blocks ABL protein from being phosphorylated.
