Pharmacology for Neuroanesthesia Flashcards

Julie Banderas, PharmD

1
Q

IV hyperosmotic drugs

A

Order of treatment:

  1. Mannitol
  2. Hypertonic saline
  3. Loop diuretics
  4. Corticosteroids
  5. Barbituates/Propofol
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2
Q

Mannitol Dosing

A
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3
Q

Mannitol best practices and monitoring/cautions

A
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4
Q

Hypertonic Saline

A
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5
Q

Loop diuretics - furosemide

A
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6
Q

Corticosteroids

A
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7
Q

Barbiturates and Propofol

A
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8
Q

Anesthesia for patients with intracranial tumors

Preoperative Management

A
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9
Q

Anesthesia for patients with intracranial tumors

Induction of Anesthesia

A
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10
Q

Anesthesia for patients with intracranial tumors

Maintenance of Anesthesia

A
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11
Q

Craniotomy surgical steps to consider

A
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12
Q

Anesthesia for craniotomy

Premedication

A
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13
Q

Anesthesia for craniotomy

Induction

A
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14
Q

Anesthesia for craniotomy

Maintenance

A
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15
Q

Maintenance - Hemodynamic management for craniotomy

A
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16
Q

Anesthesia for craniotomy

Emergence

A
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17
Q

Surgery for organ retrieval

A

Try to avoid pressors

18
Q

Acute ischemic stroke

A
19
Q

Seizure terminology and classifications

A

Focal (partial)
One hemisphere
Focused
“Key feature is preservation of awareness”

Generalized
Bilaterally affected
“:Abrupt onset of impaired consciousness”

20
Q

Antiseizure drugs - general mechanisms

A
21
Q

Antiseizure drugs - Drugs that inactivate Na+ transmission

A
22
Q

Antiseizure drugs - GABAnergic drugs

A
23
Q

Antiseizure drugs - Ca2+ channel modulating drugs

A
24
Q

Antiseizure drugs - Table showing MOA

A
25
Q

Antiseizure drugs - pharmacokinetics

A
26
Q

Antiseizure drugs - Drug interactions

A
27
Q

Phenytoin - pharmacokinetics

A

Hits Vmax quickly

Check sugars/electrolytes frequently

28
Q

Prevention of seizures

A

Know duration of action of current medications, may need perioperative dose

29
Q

Seizures during perioperative period

A
30
Q

Causes of seizures in perioperative patients

A

Test glucose before treating!

31
Q

Acute seizure management

A
32
Q

Acute seizure management
Fosphenytoin and phenytoin IV

A
33
Q

Acute seizure managment

A
35
Q

Benzodiazepines

A
36
Q

Medications for Status Epilepticus

A
37
Q

Management of Anesthesia

A
38
Q

Perioperative seizure activity

A
39
Q

Relationship between pressure and volume within the cranium

A
40
Q

Relationship between CBF and MAP

A