Clotting Factors, Trauma and Patients with Blood Disorders

Question 1

Management of perioperative bleeding consists of:

Answer 1

Question 2

Heriditary causes of hemostatic disorders

Answer 2

Question 3

Acquired causes of hemostatic disorders

Answer 3

Question 4

Factors that Contribute to Surgical Bleeding

Answer 4

Question 5

Adverse effects of surgical bleeding

Answer 5

Question 6

Normal Coagulation Process

Answer 6

Question 7

Monitoring Coagulation

Answer 7

Question 8

Thromboelastography

Answer 8

Question 9

Topical Hemostatic Agents

Answer 9

“Safer” hemostatic agents that are better at stopping active bleeding, but passive agents will not work in patients with coagulopathies.

Question 10

Methods to Achieve Surgical Hemostasis

Answer 10

Question 11

Pharmacologic Surgical Hemostasis

Answer 11

Question 12

Congenital Factor VIII Deficiency: Hemophilia A

Answer 12

• “Severe” cases the patient is spontaneously bleeding (from nose, eyes, mouth, etc.) and intervention is needed .
• Beware of the antibodies in patients that previously used recombinant factor VIII

Question 13

Desmopressin (ADH)

Answer 13

Can be used as treatment for hypernatremia

Question 14

Congenital Factor IX Deficiency: Hemophilia B

Answer 14

Question 15

Factor VII Deficiency

Answer 15

Factor VII is really what activates coagulation

Question 16

Activated Recombinant Factor VII (rFVIIa)

Answer 16

Really considered a “last line of defense”

Question 17

Clotting Factor Replacement

Answer 17

Question 18

Tranexamic Acid

Answer 18

Question 19

Warfarin Reversal

Answer 19

Question 20

DOAC Bleeding

Answer 20

Short half-life compared to Warfarin, need to know renal functioning

Question 21

Dabigatran Reversal

Answer 21

Question 22

Factor Xa Inhibitor Reversals

Answer 22

Question 23

NOAC Reversals

Answer 23