Drug Dosing Adjustments: Renal and Hepatic Dysfunction

Question 1

Loading and Maintenance Dose in Renally and Hepatically Comprimised Patients

Answer 1

Question 2

Basics of Drug Clearance

Answer 2

Question 3

Basics of Renal Clearance

Answer 3

Question 4

Stages of GFR in CKD

Answer 4

Question 5

Stages of Albuminuria in CKD

Answer 5

Question 6

Manifestation and Symptoms of CKD

Answer 6

Question 7

Renal Functioning through Creatinine Clearance

Answer 7

Question 8

Equations to Estimate GFR

Answer 8

Question 9

Estimate GFR using Cockcroft and Gault

Answer 9

CL_Cr = ((140-age) * weight (kg) * 0.85[female])/(S_Cr(mg/dl) * 72)

= (140-72) * 59 * 0.85/1 * 72

= 68 * 59 * 0.0118

= 47.36ml/min
G3a

Question 10

Estimate GFR using Cockcroft and Gault

Answer 10

CLCr = ((140-age) * weight (kg) * 0.85[female])/(SCr(mg/dl) * 72)

= (140-65) * 89 * (1/(2.6 * 72))

= 75 * 89 * 0.00534

= 35.66ml/min
G3b

Question 11

Estimate GFR using Cockcroft and Gault

Answer 11

40.6ml/min

Question 12

Estimate GFR using Cockcroft and Gault

Answer 12

CLCr = ((140-age) * weight (kg) * 0.85[female])/(SCr(mg/dl) * 72)

= ((140-45) * 104 * 1/(3.0 * 72))

= 95 * 104 * 1/216

= 45.7ml/min G3a

Question 13

Renal Drug Dosing

Answer 13

Question 14

Stepwise approach to adjust drug dosage regimens for patients with CKD and AKI

Answer 14

Question 15

Drugs With a Potential for Significant Accumulation in Patients With Renal Impairment

Answer 15

Question 16

Definition of Acute Kidney Injury

Answer 16

Question 17

Comparison of RIFLE and AKIN Criteria for AKI Definition

Answer 17

Question 18

Syndromes Associated With an Acute Decrease in GFR

What accounts for ~70% of AKI perioperatively?

Answer 18

Question 19

Urinary Indices for Differential Diagnoses

Answer 19

Question 20

Risk Factors for Perioperative AKI

Answer 20

Question 21

Estimating Renal Function in Acute Kidney Injury

Answer 21

Question 22

Intervening a patient with AKI

Answer 22

Question 23

Hepatic Dysfunction

Answer 23

Question 24

Three major parameters that determine drug elimination by the liver (3)

Answer 24

Question 25

Pathological Consequences of Hepatic Dysfunction

Answer 25

Question 26

Hepatic Drug Dosing

Answer 26

Question 27

Child-Pugh Score

Answer 27

Question 28

Anesthesia and Liver Disease

Answer 28