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Case 9 > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

What is Aciclovir used for?

A

HSV + VZV

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2
Q

What is Oseltamivir used for?

A

Influenza strains

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3
Q

What is Ribavirin used for?

A

Hep C

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4
Q

What is Zidovudine used for?

A

HIV

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5
Q

What does HAART for HIV involve?

A

Combination of 3 reverse-transcriptase inhibitors - NNRTI + 2 NRTIs
Protease inhibitor may also be used as adjuncts

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6
Q

What is the MOA of Aciclovir?

A

Acts as guanosine analogue - blocks viral DNA polymerase + limits replication

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7
Q

What is the MOA of Oseltamivir?

A

Competitive inhibitor of viral neuraminidase - limits release of new viral proteins

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8
Q

What is the MOA of Bibavirin?

A

Viral RNA nucleoside mimetic - cause lethal hypermutation during viral RNA synthesis

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9
Q

What is the MOA of Zidovudine?

A

Thymidine analogue - inhibits viral reverse transcriptase which can suppress viral DNA becoming incorporated into host genome

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10
Q

What are the ADR’s of Aciclovir?

A

Abd. pain, diarrhoea, skin irritation/inflammation

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11
Q

What are the CI’s of Aciclovir?

A

Elderly

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12
Q

What are the ADR’s of Oseltamivir?

A

Abd. pain, nausea, vomiting, dyspepsia, headache

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13
Q

What are the CI’s of Oseltamivir?

A

Pregnant

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14
Q

What are the ADR’s of Ribavirin?

A

Lots

Commonly depression, rarely haemolytic anaemia

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15
Q

What are the CI’s of Ribavirin?

A

Pregnant or pre existing CVD

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16
Q

What are the ADR’s of Zidovudine?

A

Flu like symptoms, fatigue, numerous types GI disturbances

17
Q

What are the CI’s of Zidovudine?

A

Haemopoietically suppressed patient

Case 9 (11 decks)

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