Pharmacology Flashcards
What are myofibrils?
Cylindrical structures within muscle fibre - Are bundles of protein filaments Actin (thin) and Myosin (thick)
Myosin
shaped like golf clubs. consists of 2 heavy myosin molecules wound together to form a rod portion lying parallel to the myosin myofilament and 2 heads that extend laterally.
Actin
2 strands of fibrous actin form a double helix extending the length of the myofilament - composed of G actin monomers which each have an active site - actin can bind to myosin during contraction.
what layers are the skin made up of?
Epidermis, dermis, hypodermis
The epidermis
Layer in contact with the external environment. contains various cell types - keranocytes, melanocytes, Langerhans cells, merkel cells
The dermis
Layer of dense irregular connective tissue underlying epidermis - dermal papillae - papillary layer and reticular layer - contains nerves and sensory receptors, blood vessels, glands and muscle fibres
Km stays the same but Change in Vmax
NON - competitive
Vmax stays the same but change in Km
Competitive
Receptor to pharmacologist
A target molecule through which soluble physiological mediators produce their effect
How receptor interact with ligand
Ligand + receptor –> ligand-receptor complex –> response
Agonist
Substance that interacts with specific cellular constituent and elicits an observable biological response
Inverse agonist
Acts on the same receptor of the agonist but produces an inverse effect
Antagonist
Inhibits the effect of an agonist but has no biological activity of its own. It may compete with the same receptor site that the agonist occupies or it may act on allosteric site
Efficacy
Measure of the biochemical or physiological effect which results following the binding of a drug to its target.
A measure of the maximum effect the drug can produce
Potency
Dose of drug required to produce a specific effect of given magnitude
