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GI Block > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

What is the MoA of metoclopramide?

A

inhibits the D2 receptor, which would inhibit ACh release (promotes ACh)

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2
Q

What are the toxicities ass’d with long and short-term use of metoclopramide?

A

short: acute dystonia
long: tardive dyskinesia

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3
Q

What is erythromycin’s prokinetic MoA?

A

motilin receptor agonist

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4
Q

What is the MoA of neostigmine?

A

ACh-esterase inhibitor

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5
Q

What are the toxicities of neostigmine?

A

bradycardia, AV block, cardiac arrest

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6
Q

What is the antidote for neostigmine?

A

atropine

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7
Q

What are the three drugs used for gastroparesis?

A

metoclopramide
erythromycin
neostigmine

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8
Q

What is the MoA of sucralfate?

A

form an epithelial barrier in stomach acid

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9
Q

What can be used to neutralize acid? (4)

A

Mg(OH)2
Al(OH)3
CaCO3
NaHCO3

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10
Q

What are toxicities of Al and Mg?

A

Al: constipation
Mg: diarrhea

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11
Q

What are the H2 blockers? (3)

A

ranitidine
famotidine
cimetidine

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12
Q

What is a toxicity of cimetidine?

A

CYP inhibitor

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13
Q

What are the PPIs? (5)

A 
omeprazole
esomeprazole
lansoprazole
pantoprazole
rabeprazole
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14
Q

What is an important toxicity of PPIs?

A

AIN

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15
Q

What is a prostaglandin analog?

A

misoprostol

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16
Q

What is an important toxicity for misoprostol?

A

abortifacient (pregnancy X)

17
Q

What is the MoA of ondansetron?

A

5-HT (serotonin) antagonist

18
Q

What is a toxicity of ondansetron?

A

prolonged QT

19
Q

What are the anti-emetic D2 blockers?

A

prochlorperazine

promethazine

GI Block (5 decks)

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