Pharmacology

Question 1

Are steroid hormones lipid soluble?

Answer 1

Yes

Question 2

Is NO lipid soluble?

Answer 2

Yes

Question 3

What are the 4 types of cell surface receptor?

Answer 3

Receptors that act as ion channels
Receptors with intrinsic enzyme activity
Receptors that interact with JAK kinases
Receptors that interact with G proteins

Question 4

Which class of receptor types is the largest?

Answer 4

G-protein coupled receptors

Question 5

GPCRs coupled to adenylyl cyclase produce ____ that regulates ____

Answer 5

GPCRs coupled to adenylyl cyclase produce cAMP that regulates PKA

Question 6

What does phospholipase C produce as a 2nd messenger when it’s regulated by a GPCR?

Answer 6

IP3 and DAG

Question 7

Can GPCRs regulate ion channels directly?

Answer 7

Yes

Question 8

What is affinity?

Answer 8

The strength of chemical attraction between drug and receptor

Question 9

What does a low EC50 indicate?

Answer 9

High affinity

Question 10

What is efficacy?

Answer 10

A measure of how good the drug is at activation the receptor

Question 11

Does an agonist mimic or block normal action of the receptor?

Answer 11

Mimics

Question 12

Does an antagonist mimic or block normal action of the receptor?

Answer 12

Blocks