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Musculoskeletal > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

What class of drug is Adalimumab? What is it used to treat?

A
  • Anti-TNF agent (prevents access of cytokines to target tissues)
  • rheumatoid arthritis
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2
Q

What is the mechanism of action of Celecoxib (the coxibs)?

A
  • Cox-2 selective inhibitors
  • inhibit prostaglandin synthesis but does not offer the cardioprotective effects of tranditional nonselective NSAIDS
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3
Q

What is the use of cyclobenzapyrine?

A

muscle relaxant except in the case of palsy or CNS injury

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4
Q

What drug class is Diclofenac? What is it’s MOA?

A
  • NSAID
  • decreases the availability of arachdonic acid in addtion to COX-1 and COX-2 inhibition
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5
Q

What kind of drugs should Diclofenac not be given with?

A
  • other NSAIDs
  • anticoagulants
  • anything containing aspirin
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6
Q

What are the thee uses of Diclofenac?

A
  • Rheumatoid arthritis pain
  • Osteoarthritis pain
  • Ankylosing spindylitis pain
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7
Q

What is the MOA of Etanercept? What does it treat?

A
  • inhibits TNF and therefore reduces inflammation
  • Rheumatoid arthritis, ankylosing spondylitis
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8
Q

What is the MOA and use of Fentanyl?

A
  • mu-opioid receptor agonist
  • pain management
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9
Q

What is the MOA of Ibuprofen?

A
  • NSAID
  • COX-1 and COX-2 inhibition preventing the conversion of arachdonic acid to PGG2
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10
Q

What is the MOA of Infliximab? What is it used to treat? What are its contraindications?

A
  • TNF inhibitor
  • ankylosing spondylitis, RA
  • contraindicated by live vaccines
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11
Q

What 2 NSAIDs are selective COX-2 inhibitors used to treat OA, RA, JRA, and Ankylosing spndylitis?

A
  • Meloxicam
  • Celecoxib
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12
Q

What class of drugs is methylprednisolone? What is it used to treat?

A
  • glucocorticoid
  • arthritis, rheumatoid arthritis, SLE
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13
Q

What class of drug is prednisone? What is it used to treat?

A

Glucocorticoid

-inflammatory diseases like RA, MS, MG

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14
Q

What is the MOA of Nebumetone? What is it used to treat?

A

NSAID

  • COX-1 and 2
  • OA, RA
  • do not use with antiplatelet or antihypertensive drugs
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15
Q

What is the MOA of Naproxen and what are its clinical uses? What is its notable attribute?

A
  • NSAID (COX-1 and 2)
  • only NSAID marketed as a single enatiomer
  • OA, RA, Gout, ankylosing spondylitis
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16
Q

What is the use of Carisoprodol?

A
  • muscle relaxant
  • muscle spasm and pain
17
Q

What is the MOA and use of Tramidol?

A

Musculoskeletal (9 decks)

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