Micro- Bacterial infections Flashcards
What are the two types if infective arthritis?
- Reactive (reaction to infection somewhere else)
- Spetic (direct infection of joint)
What human lymphocyte antigen (HLA) is reactive arthritis associated with?
-HLA B27
What organisms are associated with HLA B27?
Klebsiella pneumoniae
-also shigella and Yersinia
What are other common pathogens of reactive arthritis?
- Campylobacter, Salmonella, Yersinia, Shigella
- also Chlmydophila trachomatis
What a are the two major classes of septic arthritis?
- Gonococcal
- Non-gonococcal
What is the most common pathogen involved with gonococcal septic arthritis?
-Neisseria gonorrhea
–>most frequent amoung younger seucally active individuals (~75%)
What are the more common non-gnococcal pathogens of septic arthritis?
Staph Aureus–> most common in adults and children>2
Strep v..Strep pneumo. and group B strep
What are clinical symptoms of gonococcal arthritis?
- Fever
- pain in multiple joints
- Skin lesions (vesicular)
- negative culture of synovium
What are the symtoms of non-gonococcal arthritis?
-joint pain, loss of motion, hot and swollen
–>resulting from acute systemic infection
What joint is affected in adults v. children in non-gonococcal arthritis? How about IV drug users?
- Adult: knee
- Children: Hip and knee
Iv Drug Users: Sternoclavicular or sacroiliac
What organism is the primary cause of non-gonococcal septic arthritis?
-Staph aureus
A bite from what kind of organsim can cause non-gonococcal arthritis?
-Tick
What is the culture of synovial fluid like in the diagnosis of septic arthritis?
- synovial fluid culture is positive in 75% of Gram(+)
- synovial fluid culture is negative in 75% of Gram(-)
What cell count is elevated in septic arthritis? What kind of cell predominates?
- WBC elevated
- mostly neutrophils
What are the kinds acute and chronic meylitis?
Acute:
–> Hematogenous
–>direct infection
Chronic:
–>persistent necrotic bone from vascular insufficiency
