Pharmacology Flashcards
What are the 2 sub systems of autonomic system?
Symp and parasymp systems
What is the difference between the somatic and autonomic wiring system?
Somatic uses 1 neuron directly to the target/Autonomic 2 neurons (pre and postganglionic)
Where does the symp preganglionic fibers leave the CNS?
Thoracic and lumbar spinal nerves
Where does the parasymp preganglionic fibers leave the CNS?
Cranial nerves and sacral spinal nerves
Most symp preganglionic fibers terminate at the paravertebral chain, except for?
The innervation to the adrenal medulla
Symp preganglionic fibers tend to be ___ ? and postganglionic fibers tend to be ___?
short/long
Parasymp preganglionic fibers tend to be ___ ? and postganglionic fibers tend to be ___?
long/short
Somatic/parasymp pre and postganglionic/symp pregangalionic all use ___ as their NT?
ACh
Which NT does symp postganglionic fiber use?
Norepi
Symp postganglionic fibers terminate ___?
Diffusely
What are the 2 exceptions of NT that symp postganglionic fibers use?
Sweat glands—>ACh Renal vascular smooth muscle—>dopamine
The ratio of pre-postganglionic symp fibers is?
1:20 (norepi and epi released from adrenal medulla also contribute to the diffusive activation of symp)
The ratio of pre-postganglionic parasymp fibers is?
1:1—>discrete effect
ACh is made from?
acetyl-CoA and choline by choline acetyltransferase
How is ACh cleared in the synaptic cleft?
Cleaved into choline and acetate by acetylcholinesterase and recycled
Cholinoreceptor
