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KAPS Paper 1 > Pharmacology 3 Chemotherapy > Flashcards

Pharmacology 3 Chemotherapy Flashcards

1
Q

Innefective againsta candida

A

TOLNAFTATE

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2
Q

Worms present in humans but not animals

A

ASCARIS
ANCLYSTOMA
OXYRIOUS

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3
Q

Worms presnent in both human and animals

A

FASCHIOLA
HETROPHES

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4
Q

Tx antibiotic induced
PSUDO MEMBRANOUS COLITIS

A

VANCOMYCIN

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5
Q

TUBUCORARIN should not be taken with

A

GENTAMYCIN
Risk of MG - dec in ACH

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6
Q

Tx of methicillin resistant staph

A

VANCOMYCIN

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7
Q

TRIMETOPHRIM cause which SE

A

PHOTOSENSITIVITY

Also nalidixic Acid, sulfa drugs, FQ

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8
Q

Preffered over carbenicillin for CHF, Renal F, HTN

A

TICARCILLIN
Bec of small doses

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9
Q

Tetracycline should not be given in

A

PREGNANCY

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10
Q

Tetracycline gives different patterns of absorption/dissolution bacause it is

A

AMPHOTERIC
Forms acids/ bases
Internal salts

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11
Q

Mantox test is used in

A

TB

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12
Q

Tx of systemic ANAEROBIC infection

A

METRONIDAZOLE

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13
Q

Sulfamethoxazole/trim blocks seq step in synthesis of

A

FOLIC ACID

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14
Q

Sulfa drugs are long acting because of it’s

A

PLASMA PROTEIN BINDING

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15
Q

Sulfonamides SE

A

SJS

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16
Q

Causes KERNICTERUS in neonates

A

SULFISOXAZOLE

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17
Q

Are not liable to destruction by heat

A

SULFA DRUGS

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18
Q

Tx strep Viridans; subacute bacterial
endocarditis

A

AMPICILLIN
AMINOGLYCOSIDES

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19
Q

Streptococcus pyrogens-scarlet fever
is found in

A

THROAT

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20
Q

Bacterial infection:

BONE

A

STAPH AUREUS

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21
Q

Bacterial infection
PSEUDOMEMBRANOUS COLITIS

A

CLOSTRIDIUM DIFICILE

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22
Q

Bacterial infection
UTI, MENINGITIS

A

PSEUDOMONAS AUROGINOSA

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23
Q

Used in tx of gonorrhea for patient with pencillin sensitivity or
Gonococci resistance

A

SPECTINOMYCIN

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24
Q

SE of pentamidine

A

SEVERE HYPOtension

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25
Q

SE of ketoconazole

A

Headache
GIT

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26
Q

Safest sulf to allergic pts

A

SULFAMETHIZOLE

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27
Q

Rifampicin should be taken when

A

BEFORE MEALS

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28
Q

Test for disinfectant and germicidal action

A

RADIAL WALKER TEST

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29
Q

Quinolone SE

A

CNS STIMULATION

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30
Q

Used in tx of pinworms

A

PYRVINIUM PAMOATE

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31
Q

Anthelmintic that should be swallowed whole- no chewing, will cause red stool, not to be used with inflammed GIT

A

PYRVINIUM PAMOATE

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32
Q

PYRAZINAMIDE SE

A

ARTHGIA
HYPERURECEMIA

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33
Q

Cuasative organism of PURULENT BOILS in the ear

A

STAPH

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34
Q

Erythromycin+ WARFARIN

A

⬇️ warfarin concentration to half

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35
Q

Cause hemolytic anemia in G6PD

A

PRIMAQUINE

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36
Q

PostMENOPAUSAL vaginal infection is caused by

A

E. COLI

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37
Q

A non irritant bacteriostatic, sporocidal in small doses

A

PHENYL MERCURIC NITRATE

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38
Q

Effective as urinary analgesic

A

PHENAZOPYRIDINE

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39
Q

Should be taken on an epmty stomach to limit destruction by acid hydrolysis

A

PEN G TABLETS (PENTIDS)

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40
Q

Excretion of penicillin?
Aminoglycosides?

A

P- tubular
A- glumerular

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41
Q

Alternative to penicillin allergic patients

A

ERYTHROMYCIN

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42
Q

Otitis media & sinusitis is cause by

A

H. INFLUENZA, S. PNEUMONIA, MORAXELLA

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43
Q

Otitis media & sinusitis TX

A
  1. AMOXICILLIN
  2. TMP-SMZ, cefixime, cefaclor
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44
Q

Drug of choice for MONILIASIS

A

NYSTATIN
Candida Albicans

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45
Q

Tx of tinea capitis (oral)

A

GRISEOFULVIN

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46
Q

Antibiotic used in TB

A

STREPTOMYCIN

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47
Q

Tx of Gonoccoci

A

PEN G

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48
Q

Useful against G+ UTI

A

NITROFURANTOIN
More effective in acidic urine

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49
Q

Tx of tapeworm

A

NICLOSAMIDE

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50
Q

Maybe combined with vancomycin in tx of MRSA

A

RIFAMPICIN

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51
Q

Most suitable oral sulfisoxazole

A

ACETYL

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52
Q

Worm in children

A

OXYURIS (Pinworm)
Tx Mebendazole

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53
Q

MOA by growth by competitive antagonism

A

SULFONAMIDES

54
Q

MOA cell wal synthesis

A

CEPHALOSPORINS
PENICILLINS

55
Q

MOA cell membrane

A

PLOYMIXIN
NYSTATIN
AMPHO B

56
Q

Microorganism dangerous to the eye

A

PSEUDOMONAS AURUGINOSA

57
Q

Pencilinase resistant, used in G+ upper respiratory infection

A

METHICILLIN

58
Q

Pyrazinamide and INH metabolism

A

ACETYLATION

59
Q

Tx of LYME disease (Borella)

A

DOXYCYCLINE, TC
CEFTRIAXONE- severe

60
Q

Ketoconazole is CI with this drugs because it decreases acidity of stomach

A

FAMOTIDINE

61
Q

Parenteral/topical antifungal

A

AMPOTHERICIN B

62
Q

Keteconazole interacts with

A

WARFARIN
ANTACIDS
CISAPRIDE
H2 BLOCKERS/ PPI’s
AMPHO B

63
Q

Cause deafness as it affect the 8th cranial nerve

A

KANAMYCIN

64
Q

Increases methenamine acitivity by decreasing pH of urine

A

K PHOSPHATE

65
Q

K content of Pen G K is

A

1.7 meq/ millU

66
Q

Most potent anti TB

A

INH

67
Q

INH cause SE

A

LACTIC ACIDOSIS
PERIPHERAL NEURITIS

68
Q

Indicate bacteria in urine

A

NITRATES

69
Q

Most effective against G- bacteria
& P. aurogenosa

A

GENTAMYCIN

70
Q

Most effective in Alkaline urine

A

GENTAMYCIN

71
Q

Most effective in acidic urine

A

NITROFURANTOIN/ TC

72
Q

To prevent crystaluria by sulfonamides

A

PLENTY OF WATER

73
Q

Must be refrigerated

A

FLUOXACILLIN

74
Q

Salfadoxime 400mg + pyrimethamine 80 is

A

FANSIDAR

75
Q

Cause of FANCONI like syndrome

A

EXPIRED TETRACYCLINE

76
Q

Most common microorganism in complicated UTI

A

E COLI

77
Q

Drug most most appropriate to treat GONORRHEA (in poor complianc pt)

A

SPECTINOMYCIN

78
Q

H. Influenza DOC

A

AMPICILLIN

79
Q

DOC e. Coli

A

COTRIMOXAZOLE

80
Q

Pencillin is destroyed by

A

HYDROLYSIS

81
Q

Chlamydia, legionella, helicobacter tx

A

CIPROFLOXACIN

82
Q

Cirprofloxacin increase toxicity of

A

THEOPHYLLINE

83
Q

Chloramphenicol is indicated for

A

TYPHOID FEVER

84
Q

Chloramphenicol is a type of morph

A

POLYMORPHIC

85
Q

Asymptomatic in female
Dysuria in male

A

CHLAMYDIA

86
Q

Tx of meningitis

A

CEFTRIAXONE
CEFOTAXIM
crosses BBB

87
Q

Drug for tapeworm

A

THIABENDAZOLE

88
Q

Drug for pinworm, round worm

A

PYRANTEL PAMOATE

89
Q

Whip, hookworm drug

A

MEBENDAZOLE

90
Q

SE of coamoxiclav

A

CHOLESTATIC JAUNDICE
HEPATOTOXIC

91
Q

Effect against pseudomonas

A

AMINIGLYCOSIDES

92
Q

Legionnaire’s disease tx
G+ legionella pneumophila

A

ERYTHROMYCIN

93
Q

Lowest degree of toxicity, acitivity similar to ampicillin

A

ERYTHROMYCIN

94
Q

Reserved for tx of gonorrhea who faul tx with penicillin, amox, TC

A

SPECTINOMYCIN

95
Q

Adjunt therapy in UTI, lowers NH3 and Ph, engancing antibiotic effectiveness. SE: skin rash with alcohol intake, chelates iron- avoid

A

ACETOHEXAMIDE ACID (AHA)

96
Q

Not to be taken with urine alkalinizer

A

CIPROFLOXACIN

97
Q

Tx of bacterial vaginosis

A

METRONIDAZOLE

98
Q

TC with longest HALFLIFE

A

DOXYCYCLINE

99
Q

Will cause failure of contraceptive therapy

A

GRISEOFULVIN

100
Q

Released by bacteria that causes fever

A

ENDOTOXINS

101
Q

Not a side effect of aminoglycoside

A

ANEMIA
Tetracyclines

102
Q

Drug of choice for UTI

A

Trimethoprim/Sulfamethoxazole
(TMP/SMX or Bactrim):

is often used as a first-line treatment for uncomplicated UTIs.

103
Q

Drug NOT to use in glandular fever

A

AMOX

104
Q

Drugs that worsen burns

A

DOXY
KETOCONAZOLE

105
Q

Cellulitis tx

A

PENICILLIN

106
Q

Renal dose adjustment needed in

A

CHLORAMPHENICOL

107
Q

Pre dental surgery antibiotic

A

PENICILLIN

108
Q

Decreases K levels

A

AMPHOTERICIN

109
Q

Aminglycoside is contraindicated with

A

FUROSEMIDE
ototoxic

110
Q

Spore destruction is heated in autoclave at

A

100 •C (30mins) x 3 days Moist heat

111
Q

Required presence of gastric acid

A

KETOCONAZOLE

112
Q

Antibacterial with reversible MAOi

A

LINEZOLID

113
Q

INH
PAS
Hydralazine
Sulfonamides

Are metabolized by

A

ACETYLATION

114
Q

B- lactam metabolism by

A

HYDROLYSIS

115
Q

Antiviral drug not having active metabolites

A

LAMIVUDINE

116
Q

MOA or drug class of Efavirenz

A

NNRTI

117
Q

Duration of treatment for varicella zoster

A

7 days

118
Q

Viral infection of nerve root

A

SHINGLES

119
Q

MOA or drug class of SAQUINAVIR

A

PROTEASE ENZYME INHIBITOR

120
Q

Imunization against TB, is a variable strain of mycobacterium bovis

A

BCG

121
Q

Not an active immunity

A

DPT

122
Q

Tx of herpes simplex encephalatis

A

VIDARABIN

123
Q

Tx of herpes simplex of the eyelid/ conjuctiva

A

IDOXORUDINE

124
Q

Diagnostic element(antibody) in blood for HIV is detected by

A

ELISA assay

125
Q

Restriction endonuclease enzyme cut the

A

DNA

126
Q

Tx of PCP- pneumocyris pneumonia in HIV

A

PENTAMIDINE

127
Q

Tx of CMV

A

FOSCARNET
CIDOVOFIR

128
Q

Longest duration antiviral

A

DIDANOSINE

129
Q
  1. Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs):
A

LATEZ vudine

• Lamivudine (3TC)
• Abacavir (ABC
• Tenofovir (TDF)
• Emtricitabine (FTC)
• Zidovudine (AZT

130
Q
  1. Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs):
A

NERD

• Nevirapine
• Efavirenz
• Rilpivirine
• Doravirine

131
Q
  1. Protease Inhibitors (PIs):
A

LARDS navir

• Lopinavir
• Atazanavir
• Ritonavir
• Darunavir
• Saquinavir

KAPS Paper 1 (4 decks)

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