Pharmacology 3 Chemotherapy Flashcards
Innefective againsta candida
TOLNAFTATE
Worms present in humans but not animals
ASCARIS
ANCLYSTOMA
OXYRIOUS
Worms presnent in both human and animals
FASCHIOLA
HETROPHES
Tx antibiotic induced
PSUDO MEMBRANOUS COLITIS
VANCOMYCIN
TUBUCORARIN should not be taken with
GENTAMYCIN
Risk of MG - dec in ACH
Tx of methicillin resistant staph
VANCOMYCIN
TRIMETOPHRIM cause which SE
PHOTOSENSITIVITY
Also nalidixic Acid, sulfa drugs, FQ
Preffered over carbenicillin for CHF, Renal F, HTN
TICARCILLIN
Bec of small doses
Tetracycline should not be given in
PREGNANCY
Tetracycline gives different patterns of absorption/dissolution bacause it is
AMPHOTERIC
Forms acids/ bases
Internal salts
Mantox test is used in
TB
Tx of systemic ANAEROBIC infection
METRONIDAZOLE
Sulfamethoxazole/trim blocks seq step in synthesis of
FOLIC ACID
Sulfa drugs are long acting because of it’s
PLASMA PROTEIN BINDING
Sulfonamides SE
SJS
Causes KERNICTERUS in neonates
SULFISOXAZOLE
Are not liable to destruction by heat
SULFA DRUGS
Tx strep Viridans; subacute bacterial
endocarditis
AMPICILLIN
AMINOGLYCOSIDES
Streptococcus pyrogens-scarlet fever
is found in
THROAT
Bacterial infection:
BONE
STAPH AUREUS
Bacterial infection
PSEUDOMEMBRANOUS COLITIS
CLOSTRIDIUM DIFICILE
Bacterial infection
UTI, MENINGITIS
PSEUDOMONAS AUROGINOSA
Used in tx of gonorrhea for patient with pencillin sensitivity or
Gonococci resistance
SPECTINOMYCIN
SE of pentamidine
SEVERE HYPOtension
SE of ketoconazole
Headache
GIT
Safest sulf to allergic pts
SULFAMETHIZOLE
Rifampicin should be taken when
BEFORE MEALS
Test for disinfectant and germicidal action
RADIAL WALKER TEST
Quinolone SE
CNS STIMULATION
Used in tx of pinworms
PYRVINIUM PAMOATE
Anthelmintic that should be swallowed whole- no chewing, will cause red stool, not to be used with inflammed GIT
PYRVINIUM PAMOATE
PYRAZINAMIDE SE
ARTHGIA
HYPERURECEMIA
Cuasative organism of PURULENT BOILS in the ear
STAPH
Erythromycin+ WARFARIN
⬇️ warfarin concentration to half
Cause hemolytic anemia in G6PD
PRIMAQUINE
PostMENOPAUSAL vaginal infection is caused by
E. COLI
A non irritant bacteriostatic, sporocidal in small doses
PHENYL MERCURIC NITRATE
Effective as urinary analgesic
PHENAZOPYRIDINE
Should be taken on an epmty stomach to limit destruction by acid hydrolysis
PEN G TABLETS (PENTIDS)
Excretion of penicillin?
Aminoglycosides?
P- tubular
A- glumerular
Alternative to penicillin allergic patients
ERYTHROMYCIN
Otitis media & sinusitis is cause by
H. INFLUENZA, S. PNEUMONIA, MORAXELLA
Otitis media & sinusitis TX
- AMOXICILLIN
- TMP-SMZ, cefixime, cefaclor
Drug of choice for MONILIASIS
NYSTATIN
Candida Albicans
Tx of tinea capitis (oral)
GRISEOFULVIN
Antibiotic used in TB
STREPTOMYCIN
Tx of Gonoccoci
PEN G
Useful against G+ UTI
NITROFURANTOIN
More effective in acidic urine
Tx of tapeworm
NICLOSAMIDE
Maybe combined with vancomycin in tx of MRSA
RIFAMPICIN
Most suitable oral sulfisoxazole
ACETYL
Worm in children
OXYURIS (Pinworm)
Tx Mebendazole
MOA by growth by competitive antagonism
SULFONAMIDES
MOA cell wal synthesis
CEPHALOSPORINS
PENICILLINS
MOA cell membrane
PLOYMIXIN
NYSTATIN
AMPHO B
Microorganism dangerous to the eye
PSEUDOMONAS AURUGINOSA
Pencilinase resistant, used in G+ upper respiratory infection
METHICILLIN
Pyrazinamide and INH metabolism
ACETYLATION
Tx of LYME disease (Borella)
DOXYCYCLINE, TC
CEFTRIAXONE- severe
Ketoconazole is CI with this drugs because it decreases acidity of stomach
FAMOTIDINE
Parenteral/topical antifungal
AMPOTHERICIN B
Keteconazole interacts with
WARFARIN
ANTACIDS
CISAPRIDE
H2 BLOCKERS/ PPI’s
AMPHO B
Cause deafness as it affect the 8th cranial nerve
KANAMYCIN
Increases methenamine acitivity by decreasing pH of urine
K PHOSPHATE
K content of Pen G K is
1.7 meq/ millU
Most potent anti TB
INH
INH cause SE
LACTIC ACIDOSIS
PERIPHERAL NEURITIS
Indicate bacteria in urine
NITRATES
Most effective against G- bacteria
& P. aurogenosa
GENTAMYCIN
Most effective in Alkaline urine
GENTAMYCIN
Most effective in acidic urine
NITROFURANTOIN/ TC
To prevent crystaluria by sulfonamides
PLENTY OF WATER
Must be refrigerated
FLUOXACILLIN
Salfadoxime 400mg + pyrimethamine 80 is
FANSIDAR
Cause of FANCONI like syndrome
EXPIRED TETRACYCLINE
Most common microorganism in complicated UTI
E COLI
Drug most most appropriate to treat GONORRHEA (in poor complianc pt)
SPECTINOMYCIN
H. Influenza DOC
AMPICILLIN
DOC e. Coli
COTRIMOXAZOLE
Pencillin is destroyed by
HYDROLYSIS
Chlamydia, legionella, helicobacter tx
CIPROFLOXACIN
Cirprofloxacin increase toxicity of
THEOPHYLLINE
Chloramphenicol is indicated for
TYPHOID FEVER
Chloramphenicol is a type of morph
POLYMORPHIC
Asymptomatic in female
Dysuria in male
CHLAMYDIA
Tx of meningitis
CEFTRIAXONE
CEFOTAXIM
crosses BBB
Drug for tapeworm
THIABENDAZOLE
Drug for pinworm, round worm
PYRANTEL PAMOATE
Whip, hookworm drug
MEBENDAZOLE
SE of coamoxiclav
CHOLESTATIC JAUNDICE
HEPATOTOXIC
Effect against pseudomonas
AMINIGLYCOSIDES
Legionnaire’s disease tx
G+ legionella pneumophila
ERYTHROMYCIN
Lowest degree of toxicity, acitivity similar to ampicillin
ERYTHROMYCIN
Reserved for tx of gonorrhea who faul tx with penicillin, amox, TC
SPECTINOMYCIN
Adjunt therapy in UTI, lowers NH3 and Ph, engancing antibiotic effectiveness. SE: skin rash with alcohol intake, chelates iron- avoid
ACETOHEXAMIDE ACID (AHA)
Not to be taken with urine alkalinizer
CIPROFLOXACIN
Tx of bacterial vaginosis
METRONIDAZOLE
TC with longest HALFLIFE
DOXYCYCLINE
Will cause failure of contraceptive therapy
GRISEOFULVIN
Released by bacteria that causes fever
ENDOTOXINS
Not a side effect of aminoglycoside
ANEMIA
Tetracyclines
Drug of choice for UTI
Trimethoprim/Sulfamethoxazole
(TMP/SMX or Bactrim):
is often used as a first-line treatment for uncomplicated UTIs.
Drug NOT to use in glandular fever
AMOX
Drugs that worsen burns
DOXY
KETOCONAZOLE
Cellulitis tx
PENICILLIN
Renal dose adjustment needed in
CHLORAMPHENICOL
Pre dental surgery antibiotic
PENICILLIN
Decreases K levels
AMPHOTERICIN
Aminglycoside is contraindicated with
FUROSEMIDE
ototoxic
Spore destruction is heated in autoclave at
100 •C (30mins) x 3 days Moist heat
Required presence of gastric acid
KETOCONAZOLE
Antibacterial with reversible MAOi
LINEZOLID
INH
PAS
Hydralazine
Sulfonamides
Are metabolized by
ACETYLATION
B- lactam metabolism by
HYDROLYSIS
Antiviral drug not having active metabolites
LAMIVUDINE
MOA or drug class of Efavirenz
NNRTI
Duration of treatment for varicella zoster
7 days
Viral infection of nerve root
SHINGLES
MOA or drug class of SAQUINAVIR
PROTEASE ENZYME INHIBITOR
Imunization against TB, is a variable strain of mycobacterium bovis
BCG
Not an active immunity
DPT
Tx of herpes simplex encephalatis
VIDARABIN
Tx of herpes simplex of the eyelid/ conjuctiva
IDOXORUDINE
Diagnostic element(antibody) in blood for HIV is detected by
ELISA assay
Restriction endonuclease enzyme cut the
DNA
Tx of PCP- pneumocyris pneumonia in HIV
PENTAMIDINE
Tx of CMV
FOSCARNET
CIDOVOFIR
Longest duration antiviral
DIDANOSINE
- Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (NRTIs):
LATEZ vudine
• Lamivudine (3TC)
• Abacavir (ABC
• Tenofovir (TDF)
• Emtricitabine (FTC)
• Zidovudine (AZT
- Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs):
NERD
• Nevirapine
• Efavirenz
• Rilpivirine
• Doravirine
- Protease Inhibitors (PIs):
LARDS navir
• Lopinavir
• Atazanavir
• Ritonavir
• Darunavir
• Saquinavir
