CHEMISTRY Flashcards
DICARBOXYLIC ACIDS
OH MY SUCH GOOD APPLE PIE, SWEET AS SUGAR:
Oxalic acid (HOOC-COOH)
Malonic acid (HOOC-CH2-COOH)
Succinic acid (HOOC-CH2-CH2-COOH)
Glutaric acid (HOOC-(CH2)3-COOH)
Adipic acid (HOOC-(CH2)4-COOH)
Pimelic acid (HOOC-(CH2)5-COOH)
Suberic acid (HOOC-(CH2)6-COOH)
Azelaic acid (HOOC-(CH2)7-COOH)
Sebacic acid (HOOC-(CH2)8-COOH)
monocarboxylic acids
THE FLIGHT ATTENDANT OF THE PLANE BUY A VALERIAN CAP TO ENTERTAIN CAPRIL AND PELARGO
Formic acid (HCOOH)
Acetic acid (CH3COOH)
Propionic acid (CH3CH2COOH)
Butyric acid (CH3CH2CH2COOH)
Valeric acid (CH3(CH2)3COOH)
Caproic acid (CH3(CH2)4COOH)
Enanthic acid (CH3(CH2)5COOH)
Caprylic acid (CH3(CH2)6COOH)
Pelargonic acid (CH3(CH2)7COOH)
ARRANGEMENT ACCORDING TO ACIDITY
ELEMENT
most electronegative
BCNOF flourine most
heaviest
FClBrI Iodine most
RESONANCE- aromatic rings
CONDUCTIVITY- no of electronegative atoms
HYBRIDIZATION- sp or triple bond most acidic
Type of prodrugs
1.carrier
2.bioprecursor
Type of carrier prodrugs
- Bipartite
- Tripartite
- Codrugs
Activation of carrier prodrug is cause by which reaction
Hydrolysis
Activation of bioprecursor prodrugs is cause by?
Redox
Chemical groups having similar physicochemical properties
Which give similar biological effects
Bioisosteres
Phase 1 metebolism reactions:
HORD
Hydrolysis
Oxidation- CYP450
Reduction
Deamination
In phase 2 glucoronidation metabolism, which enzyme facilitates the reaction?
UDP glucoronosyl transferase
Metabolic pathway/conjugation present in neonates/ infants (Sanggol)
Sulfate conjugation
Paracetamol is metabolized by which conjugation process?
Glutathione Conjugation
Carbohydrates contains which functional groups
Carbonyl group:
Ketones R-C=O-R
Aldehydes R-C=O-H
+Polyalcohols -OH
Suffix of monosaccharides containing ketone group
-ulose
Disacharide MALTOSE composition
2 glucose
Disacharide LACTOSE composition
Gluc/galactose
Disacharide SUCROSE composition
Gluc/Fructose
Trisaccharide RAFFINOSE composition
Gluc/fruc/galactose
Tetrasaccharide STACHYOSE composition
Gluc/fruc/ 2-galactose
Metabolic process which converts GLUCOSE into PYRUVATE
GLYCOLYSIS
10 steps of glycolisis
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1. Glucose phosphorylation
2. Isomerization of glucose-6-phosphate
3. Second phosphorylation
4. Cleavage of fructose-1,6-bisphosphate
5. Isomerization of dihydroxyacetone phosphate
6. Phosphorylation of 3-phosphoglycerate
7. Conversion of 3-phosphoglycerate to 2-phosphoglycerate
8. Enolase-mediated dehydration
9. Phosphorylation of 2-phosphoglycerate
10. Substrate-level phosphorylation to generate pyruvate
Meaning of Mnemonics DGB
In great grandma throws fresh fruits DISH & GO BY picking pumpkins to prepare pies
-10 steps of glycolysis
DihydroxyAcetone Phosphate
GlycerAldehyde 3-Phosphate
1,3- BiphosphoGlycerate
Enzymes involved in glycolysis metabolism
He Put the Phone And Tried to Get the Plastic Plate to Eat Pie
Hexokinase
PhosphoFructo Isomerase
PhosphoFructoKinase
Aldolase
Trios Phosphate Isomerase
Glyceraldehyde 3-Phosphate Dehydrogenase
PhosphoGlyceroKinase
PhosphoGlyceroMutase
Enolase
Pyruvate Kinase
No. Of ATP yeilded from GLYCOLYSIS
5 or 7
End product of ANAEROBIC glycolysis in vertebrates
L-lactate
Total ATP yield = 2
By enzyme LACTATE DEHYDROGENASE
End product of ANAEROBIC glycolysis in microorganisms
Ethanol
By enzyme- PYRUVATE DECARBOXYLASE
Gluconeogenesis will covert pyruvate to oxaloacetate- G6P by the enzyme
PYRUVATE CARBOXYLASE
End product of AEROBIC glycolysis
Acetyl-CoA
Major pathway for formation of ATP. Also provides substrate for gluconeogenesis, AA & FA synthesis
TCA/ CITRIC ACID/ KREB’s cycle
Occuring in mitochondria
End products of KREB’s CYCLE
2 CO2
1 GTP
3 NADH
1 FADH2
RLS (rate limiting step) of KREB’s CYCLE
Conversion of
Isocitrate to
alpha-ketoglutarate
By enzyme isocitrate dehydrogenase
RLS (rate limiting step) of glycolysis
conversion of
fructose-6-phosphate
to fructose-1,6-bisphosphate
4 fates of PYRUVATE
Ethanol- microorganisms ANAErobic
Lactate- vertebrates ANAErobic
G6P- gluconeogenis
Acetyl-CoA- AEROBIC
Substrates (steps) of Kreb’s cycle/citric Ac/ TCA
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Oxaloacetate
Citrate
Aconitate
Isocitrate
α-Ketoglutarate
Succinyl-CoA
Succinate
Fumarate
Malate
Total ATP yeild from TCA
10 ATP
Total ATP yeild of complete glucose oxidation
30/32 ATP
The substrates for gluconeogenesis, which is the process of synthesizing glucose from non-carbohydrate precursors, include:
- Pyruvate
- Lactate
- Glycerol (from triglycerides)
- Glucogenic amino acids (amino acids that can be converted to intermediates of the Kreb cycle)
Reverse of glycolysis
A metabolic pathway in which lactate produced by anaerobic glycolysis in muscles is transported to the liver and converted back to glucose.
CORI CYCLE
- GSD Type I (Von Gierke Disease):
• Defective Enzyme:
Glucose-6-phosphatase
- GSD Type II (Pompe Disease):
• Defective Enzyme:
Acid alpha-glucosidase (GAA)
- GSD Type III (Cori Disease):
• Defective Enzyme:
Glycogen debranching enzyme (Amylo-1,6-glucosidase)
- GSD Type IV (Andersen Disease):
• Defective Enzyme:
Glycogen branching enzyme (GBE1)
- GSD Type V (McArdle Disease):
• Defective Enzyme:
Muscle glycogen phosphorylase
- GSD Type VI (Hers Disease):
• Defective Enzyme:
Liver glycogen phosphorylase
- GSD Type IX:
• Various subtypes with defects in different enzymes like
phosphorylase kinase, phosphoglucomutase, and others depending on the subtype.
Glycogen storage diseases (GSDs)
VPCAMHT
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1. GSD Type I: Von Gierke Disease 2. GSD Type II: Pompe Disease 3. GSD Type III: Cori Disease 4. GSD Type IV: Andersen Disease 5. GSD Type V: McArdle Disease 6. GSD Type VI: Hers Disease 7. GSD Type VII: Tarui
The biochemical process through which glycogen, a polysaccharide composed of glucose units, is broken down into glucose molecules
Glycogenolysis
also known as the pentose phosphate pathway (PPP) or phosphogluconate pathway, is a series of biochemical reactions that occur in the cytoplasm of cells.
Hexose Monophosphate (HMP) shunt
G6PD- RLS
Amino Acid chemical structure
.
H O
| ||
NH2—-C—-C–OH
|
R
Side chain
Amino acid not optically active
GLYSINE
amino acids along with their three-letter codes:
1. Alanine 2. Arginine 3. Asparagine 4. Aspartic acid 5. Cysteine
amino acids along with their three-letter codes:
1. Ala 2. Arg 3. Asn 4. Asp 5. Cys
amino acids along with their three-letter codes:
6. Glutamine
7. Glutamic acid
8. Glycine
9. Histidine
10. Isoleucine
- Gln or Q
- Glu or E
- Gly or G
- His
- Ile
amino acids along with their three-letter codes:
11. Leucine
12. Lysine
13. Methionine
14. Phenylalanine
15. Proline
- Leu
- Lys
- Met
- Phe
- Pro
amino acids along with their three-letter codes:
16. Serine
17. Threonine
18. Tryptophan
19. Tyrosine
20. Valine
- Ser
- Thr
- Trp or W
- Tyr
- Val
The one letter code for tryptophan
W
The one letter code for glutamic acid
E
Amino acids which are not synthesized by the body
Essential amino acids
10 essential amino acids
PVT TIM HALL
always ARGues never TYRes
1. Phenylalanine (Phe)
2. Valine (Val)
3. Threonine (Thr)
4. Tryptophan (Trp)
5. Isoleucine (Ile)
6. Methionine (Met)
7. Histidine (His)
8. Arginine (Arg)
9. Leucine (Leu)
10. Lysine (Lys)
Semi essential amino acids
HArg
HISTIDINE
ARGININE
Amino acids that undergoes glucogenic/ketogenic metabolism
WIFY
Tryptophan- W
Isoliucine- I
Phenylalanine- F
Tyrosine- Y
Amino acids metabolic products
Glucogenic Metabolism - glucose
Ketogenic Metabolism- Acetyl CoA
Amino acids that undergo ketogenic metabolism
Leu Ly
Leucine
Lysine
Amino acids: Non polar alipathic R groups
Glycine
Alanine
Valine
Leucine
Isoleucine
Methionine
.
COOH-
|
H3N+—-C—–H
|
H
Glycine
.
COOH-
|
H3N+—-C—–H
|
CH3
Alanine
.
COOH-
|
H3N+—-C—–H
|
CH
^
CH3 CH3
Valine
.
COOH-
|
H3N+—-C—–H
|
CH2
|
CH
^
CH3 CH3
Leucine
.
COOH-
|
H3N+—-C—–H
|
CH2
|
CH2
|
S
|
CH3
Methionine
.
COOH-
|
H3N+—-C—–H
|
H—-C—-CH3
|
CH2
|
CH3
Isoleucine
Amino acids: Non polar AROMATIC R groups
Phenylalanin
Tyrosine
Tryptophan
.
COOH-
|
H3N+—-C—–H
|
CH2
|
^
|o|
v
Phenylalanine
.
COOH-
|
H3N+—-C—–H
|
CH2
|
^
|o|
v
|
OH
Tyrosine