Pharmacology 2 Flashcards
Phenolpthalin and castor oil are
Stimulant laxatives or
Intestinal irritants
Metamucil, psyllium husk, bran and dietary fibers are
BULK LAXATIVES
Mg citrate and Na biphosphate are which type of laxative
OSMOTIC
Na docusate is which type of laxative
SURFACE TENSION (softener)
Dioctyl Na sulfosuccinate is also known as
DOCUSATE
In laxative do not give ____ with mineral oil
COLACE
Ca polycarbophyl is used in tx of
CONSTIPATION
Glucocorticoid with highest potency
DEXAMETHASONE
Glucocorticoid release is controlled by
HYPOTHALAMUS
Prednisolone
Methylpred
Dexameth
Betamethasones
Are examples of
GLUCOCORTICOIDS
Metoclopramide ADR that requires monitoring
TARDIVE DYSKINESIA
Pencillin loses it’s activity by which reaction
HYDROLYSIS
Drug that decreases PRELOAD
NITRATES
Drugs that decreases AFTERLOAD
HYDRALAZINE
DIAZOXIDE
Drug that decrease PRE/AFTERload
NA nitroprusside
The drug with patient instructuction as:
Apply with non metalic applicator or tip to avoid erythema
Do not cover with occlusive dressing
Avoid prolonged sunlight/UV exposure
FLUOROURACIL
Indicated for estrogen dependent neoplasm
TAMOXIFEN
Drug with storage instruction:
Room temp do not refrigerate
Protect from light
Discard unused portion
CISPLATIN
Cisplatin SE
NEPHPROTOXIC
Tx of cisplatin toxicity
AMIFOSTINE
Nitrogen mustard
Chlorambucil
Cyclophosphamide
Are which kind of cancer drugs?
ALKYLATING AGENTS
MTX
6-Mercaptopurin (6-MP)
5-FU
Are which kind of cancer drugs?
Antimetabolites
Prednisolone
Chlorambucil
Rho immunoglobulin
6-MP
Are useful ____ in chemotherapy
IMMUNOSUPPRESSANTS
The max time before bone marrow depression (BMD) occur
NADIR
Used in MTX toxicity
FOLIC/linic ACID
Is Na mercapto ethane sulfonate
MESNA
Alkylating agent which is a potent vesicant
MECHLOETHAMINE
Tx for extravasation/
unintentional leakage or escape of a fluid
THIOSULFATE
COLD COMPRESS
A granulocyte stimulating factor which stimulate the production of neutrophils
FILGRASTIM
Used in the treatment of lung cancer, testicular cancer, and certain types of lymphomas and leukemias. It may be used alone or in combination.
ETOPUSIDE
topoisomerase inhibitors. works by interfering with the DNA replication process of rapidly dividing cells, particularly cancer cells.
Anti cancer drug that is causing cardiac cumulative tocicity
DOXURUBICIN
Tx of breast/non small breast cancer
DOCETAXEL
Antibiotics use in cancer therapy
DACTINOMYCIN
MITHROMYCIN
Cytarabine is not alkylating agent
Cytarabine
Cause total bone marrow depression
CYCLOPHOSPHAMIDE
Side effect of cyclophosphamide
HEMORRHAGIC CYSTITIS
Hemmorhagic cystitis cause by cyclophosphamide is treated with
MESNA
Bone marrow depression will lead to
AGRANULOCYTOSIS
Tx of cisplatin toxicity
AMIFOSTINE
Toxicity Caused by guanin e synthesis
6- thioguanine toxicity
5-FU causes which SE
MARKER BMD
Metastatic bone pain is treated by
FENTANYL PATCH
Used in methotrexate infusion to prevent toxicity
FOLIC ACID
Methotrexate toxicity treatment
LEUCOVORIN
shows higher activity because it differs to hydrocortisone in conformation in ring A
Prednisolone
Which drug has the following complications:
Dessimination of local infection, infection susceptibility, masking symptoms of infection, osteoporosis
CORTICOSTEROIDS
Fluoridated corticosteroids are CI in
ROSACEA
Fludrocortisone is use in tx of
ADDISON’s disease
Drug class that function as intermediate in metabolism, salt & water retention, muscle development and homeostasis
CORTICOSTEROIDS
Cortisol use can lead to rash on the face due to
TELANGIECTASIAS
small, dilated blood vessels near the surface of the skin, commonly referred to as spider veins or broken blood vessels.
SJS
Longterm use of corticosteroids will cause
OSTEOPENIA
bone mineral density that is lower than normal but not low enough to be classified as osteoporosis
Relative potencies of different CORTICOSTEROIDS
Relative Potencies (Anti-inflammatory Effects):
• Cortisol (hydrocortisone): 1 (as std) • Prednisone: 4-5 times • Methylprednisolone: 5-6 times • Dexamethasone: 25-30
Equivalent Doses (mg) of different CORTICOSTEROIDS
Equivalent Doses (mg):
• Hydrocortisone: 20 mg
• Prednisone: 5 mg
• Methylprednisolone: 4 mg
• Dexamethasone: 0.75 mg
Sodium-Retaining Potencies (Mineralocorticoid Activity) of different CORTICOSTEROIDS
Sodium-Retaining Potencies (Mineralocorticoid Activity):
• Cortisol (hydrocortisone): Significant
• Prednisone: Moderate
• Methylprednisolone: Moderate
• Dexamethasone: Minimal
Cough receptors are located in the
Brain stem- medulla
Ipecac expectorant dose
1ml
Use in depolymerization of mucous
BROMHEXINE
Acetyl cystein is given by
INHALATION
Tx of cystic fibrosis
Dornase
NAC
PANCREATIN
is a genetic disorder that primarily affects the respiratory and digestive systems. This leads to the production of thick and sticky mucus, which can clog the airways and ducts in various organs, such as the lungs and pancreas.
CYSTIC FIBROSIS
There is a change in ____ in cystic fibrosis. Sx
SWEAT
Diagnostic test for cystic fibrosis
FEV-1
Chloride in sweat
% occurence of different RNA
rRNA- 80%
tRNA- 15%
mRNA- 5%
NEVIRAPINE drug class
NNRTI
Kreb’s cycle occurs in
MITOCHONDRIA
(Respiration)
Storage in cell
GOLGI APARATUS
Contains cellular digestive enzyme
LYSOSOMES
Lipid synthesys in cell occurs in
SMOOTH ER
Protein synthesys in cell occurs in
ROUGH ER
RNA with specific amino acid attached
tRNA
Drug metabolism occur in which part of the cell
ER/ RIBOSOMES
Podophyllum resin is used in the tx of
WARTS
Otc drugs for Lice
PYRETHRINS
PIPERONYL BUTOXIDE
PTEROLLATUM DISTILLATE
Rx drugs for lice
CRETAMITON
Tx of rosacea
HYDROCORTISONE
Minocycline SE
NVD
VESTIBULAR TOXICITY
Epidermis is also known as
KERATIN
Substance that remove comedones
Al(OH)3
T or f, impetigo can complicate to endocarditis
False
Tx of acne and psoriasis
TRAZOTENE
Toxic effects of clindamycin may be increased by
LOMOTIL
Loperamide in ulcerative colitis will produce
INTESTINAL PERFORATION
Related to miperidine, which stimulates the opiate center in GIT causing constipation
DIPHENOXYLATE
Citrate use in ORS
- Alkalinizing Agent:
- Enhance the flavor
MAOi can take red meat 🥩 but not
Wine
Beer
Chicken Liver
Cheese
TCA with least anticholinergic SE
TRAZODON
Tranyl cypromine is a
MAOi ANTIDEPRESSANT
Lithium concentration is decreased by
THEOPHYLLINE
Onset of TCA requires
3-4 weeks
TCA should not be used together with
GUANTIDINE
- alpha2 agonist
TCA is CI in which eye disease
GLAUCOMA
also SEDATION
ANTICHOLINERGIC effects
TACHYCARDIA
TCA + MAOi
⬆️ action of MAOi
Antidepressant classes
TCA
MAOi
ALPHA blockers
Tranylcypromine
Ampethamine
Phenylephrine
Ephedrine
Tyramine + MAOi’s
HYPERTENSIVE CRISIS
Affects neural amine reuptake mechanisms
(Serotonin, NE)
TCA
Sertraline and fluoxetine belongs to which drug class
ANTIDEPRESSANTS- SSRI
SE of cyclobenzaprine is similar to
AMITRYPTILINE
Common SE of antidepressants
Antimuscarinic effects
Postural hypotension
Drowsiness
Venlafaxin specific SE
HTN
Patient on Li should not restrict which intake
SODIUM
Tranylcypromine should restict intake of
FOOD AND DRUGS
Pseudoephedrine should take precaution in taking
IPRONIAZID
A MAOi requiring dietary restriction
PROCARBAZINE
Inhibits reuptake of 5HT - increase conc
SE: Heparic failure
CI: Cisapride, TCA, MAOi, Terfinadine, astimazole
NEFAZODONE
Use of MAOi’s
PSYCHOTROPIC
ANTIDEPRESSANT
ANTIEPILEPTIC
MAOi’s SE:
HALLUCINATIONS
TREMORS
HYPERTHERMIA
ANTICHOLINERGIC effects
Tranylcypromine
Phenelzine
Meclobimide
Iproniazide
Belongs to which antidepressant class
MAOi’s
Used in bipolar disorder but causes SE: diabetes insipidus
LITHIUM
Lithium is used in bipolar disorder but causes SE: diabetes insipidus, hypothyroidism, convulsion(treated by?)
VASOPRESSIN
A MAOi antidepressant used with caution with TCA, Tyramine, levodopa, cathecolamines, pethidine, rawoulfia
IPRONIAZID
⬇️action of adrenergic blockers
⬆️action of oral hypoglycemics
Drugs for bipolar mood disturbances
LITHIUM
CARBAMEZEPINE
NA VALPROATE
Imipramine metabolized by demethhlation will yeild
DESIPRAMINE
SE of nortryptiline
CONSTIPATION
Impiramine + oral anticoagulant
⬆️ action of imipramine
Trazodone + MAOi
SEROTONIN SYNDROME
L-dopa + MAOi
HTN CRISIS
Methylphenidate + MAOi
⬆️ CNS STIMULATION
Anti hypertensive effect of guanethidine is inhibited by
TCA (Amitryptiline)
glaucoma, a condition characterized by increased intraocular pressure that can lead to optic nerve damage. These include:
1. Prostaglandin Analogs: They help reduce intraocular pressure by increasing the drainage of aqueous humor.
Examples include
latanoprost and
travoprost.
glaucoma, a condition characterized by increased intraocular pressure that can lead to optic nerve damage. These include:
Beta-blockers:
decrease the production of aqueous humor, thereby lowering intraocular pressure.
timolol and
betaxolol
glaucoma, a condition characterized by increased intraocular pressure that can lead to optic nerve damage. These include:
Alpha Agonists:
reduces intraocular pressure by decreasing aqueous humor production and increasing its outflow.
Brimonidine
glaucoma, a condition characterized by increased intraocular pressure that can lead to optic nerve damage. These include:
Carbonic Anhydrase Inhibitors:
reduce intraocular pressure by inhibiting carbonic anhydrase, slowing down aqueous humor production.
Dorzolamide and
brinzolamide
glaucoma, a condition characterized by increased intraocular pressure that can lead to optic nerve damage. These include:
Rho Kinase Inhibitors:
increases the outflow of aqueous humor.
Netarsudil
is a prodrug, meaning it gets converted to epinephrine (adrenaline) in the eye, which then helps reduce intraocular pressure by increasing the outflow of aqueous humor
Dipivefrin
Eyedrop not destroyed by heat (autoclave)
SULFACETAMIDE
Preservatives in eye drops
Cetrimide 0.005%
Benzalkonium Cl 0.02%
Phenyl Hg nitrate 0.02%
Cholrocresol 0.1%
Chlorhexidine 0.1%
Na edetate 0.1%
Chlorambutol 0.5%
Eyedrops storage condition of 2-8 •C
CORTISONE ED
PHOSPHOLINE ED
Tx of allergic conjuctivitis
LOTEPREDNOL
Dose increment of latanoprost
30mg/day
Cyclopentolate is an eye drop medication commonly used as a mydriatic agent, meaning it dilates the pupil. Answer if asked to choose the odd among the group of miotic agents such as
morphine, codeine, epinephrine,
pilocarpine, bromocriptine
physostigmine/neostigmine
pramipexole, timolol
Several drugs have been associated with visual disturbances as potential side effects.
HAPDE
Hydroxychloroquine/Chloroquine
Amiodarone- microdeposits, blur, photoS
PDE-5 Inhibitors: color
Digoxin: blurred or yellow-tinted
Ethambutol: color
Contraindicate in NARROW angle glaucoma
ATROPINE
HOMATROPINE
EPINEPHRINE
Timolol afvantage over pilicarpine
LONGER DURATION
NO VISUAL ACCOMODATION
MINIMAL EFFECT- pupil size
Short acting mydriatic effect
ADRENALINE
Shelf life of Eyedrops
28 days
Duration of mydriasis by tropicamide
3-4 hours
Dose for ocusert pilo
Pilo 20- 20mcg/hr
Pilo 40- 40mcg/hr
Covering a week
Demographics of narrow angle glaucoma
10% of all glaucoma population
Miotic effect of this drug:
Starts in 15-30mins
Max reduction IOP in 2-4 hrs
Duration 4-8 hrs
For open angle galucoma, causing constriction of pupil and producing dimming night vision
PILOCARPINE
Eyedrops that is 3 hours shorter duration than atropine
CYCLOPHENTOLATE
TROPICAMIDE
Used as replacement to pilocarpine intolerance/resistance
CARBACHOL
Eye drops for eye lid edema
GUANTHIDINE
syndrome is a chromosomal disorder that occurs in males and is characterized by the presence of one or more extra X chromosomes.
Physical Features: physical characteristics such as tall stature, reduced muscle mass, gynecomastia (enlarged breasts), and a small testicular
Klinefelter syndrome
A uricosuric agent that increase excretion of uric acid
PROBENECID
Uric acid is a derivative of
PURINE
Tophus is also known as
GOUT
Probenecid should not be combined with these drugS
ASPIRIN
INDOMETHACIN
THIAZIDE
Phenylbutazone is used in
GOUT
Not to be taken with tea
ALLOPURINOL
Drug used it tx of gout that does not affect urate metabolism or secretion, it interferes inflammatory response to gout
COLCHICENE
Combination of Allopurinol (oxidation) with azathioprine and 6-MP will result to
⬆️concentration of azathioprine and 6-MP
Not thioguanine- methylation
Allopurinol are safe to take with
Warfarin
CPM
Inhibits xanthine oxidase
ALLOPURINOL
Counselling: drink plenty of water
Decreases uricosuric effect of probenacid
ACETAMINOPHEN
an older term for what is now commonly referred to as Polycystic Ovary Syndrome (PCOS).
Hyperandrogenism: Elevated levels of androgens (male hormones)
Stein-Leventhal syndrome
Skin contraceptive implant
LEVONORGESTREL
Antiemetic and apetite stimulant
DRONABINOL
Antiemetic that is
CI with hypokalemic
Hypomagnesemia
Anti arrhythmias
DOLASETRON
Anti emetic/ anthelmintic
TARTAR emetic
No longer used - toxicity
Vitamin CI with levodopa, parkinson, phenytoin
B6- PYRIDOXINE
A heat liable vitamin used in tx of BERIBERI (Wernicke-Korsakoff)
B1- Thiamine
Vitamin that is a precurson for NAD/FADH
Vit B2- Riboflavin
Also known as panthotenic acid
Vit B5
Niacin deficiency will result to
PELLAGRA
Cyanocobalamine deficiency
Pernicious Anemia
Impairs vitamin K absorption
MINERAL OIL
Phytonadione
menadione is
P- Vit K1
M- Vit K2
Folic in pregnancy to prevent
SPINA BIFIDA
Fish liver oil contains
VIT a/d
Iron form least absorbed by intestines
FERRIC
Vitamin with lactone structure
VITAMIN C
Vitamine with steroid structure
VITAMIN D
Ascorbic acid with methenamine is used for
URINARY CYSTITIS
Probucol is
ANTIHYPERLIPIDEMIC
Most common SE of simvastatin
HEPATOTOXIC
Drug interaction simvastatin + warfarin
Inhibit warfarin metabolism
BLEEDING
TXA2 cause
Platelet agregation
Primary response to antigen
T/B cells
T cells matures in
THYMUS GLAND
IMMUNOGLOBULIN
• Role: Found in mucous membranes, saliva, tears, and other bodily fluids, helps prevent pathogens from entering the body through mucosal surfaces. It plays a key role in local immune defense.
- IgA (Immunoglobulin A)
IMMUNOGLOBULIN
• Role: Although its precise function is not fully understood, is primarily found on the surface of B cells, where it may be involved in the activation of these cells during the immune response.
IgD (Immunoglobulin D)
Immunoglobulin
• Role: Associated with allergic reactions, binds to mast cells and basophils. Upon exposure to allergens, triggers the release of histamine and other chemicals, leading to allergic symptoms.
- IgE (Immunoglobulin E):
IMMUNOGLOBULIN
• Role: The most abundant antibody in the bloodstream, provides long-term immunity. It can cross the placenta, providing passive immunity to the fetus. is crucial for neutralizing toxins and enhancing phagocytosis.
IgG (Immunoglobulin G):
IMMUNOGLOBULIN
• Role: Produced in the early stages of an immune response, is often the first antibody to appear after exposure to an antigen. It is effective at agglutination (clumping) of pathogens.
IgM (Immunoglobulin M)
Hypersensitivity TYPE
• Mechanism: Involves IgE antibodies and mast cells or basophils.
• Examples: Allergic reactions such as hay fever, asthma, anaphylaxis to bee stings, or certain foods.
- Type I Hypersensitivity (Immediate Hypersensitivity):
Hypersensitivity TYPE
• Mechanism: Involves antibodies (IgG or IgM) targeting cell surface antigens, leading to cell destruction.
• Examples: Blood transfusion reactions, autoimmune hemolytic anemia, and certain drug reactions.
- Type II Hypersensitivity (Cytotoxic Hypersensitivity):
Hypersensitivity TYPE
• Mechanism: Involves immune complexes (antigen-antibody complexes) that deposit in tissues, causing inflammation and damage.
• Examples: Systemic lupus erythematosus (SLE), rheumatoid arthritis, and certain forms of vasculitis.
- Type III Hypersensitivity (Immune Complex-Mediated Hypersensitivity):
HYPERSENSITIVITY TYPE
• Mechanism: Involves T cells (specifically, cytotoxic T cells or helper T cells) and does not involve antibodies.
• Examples: Contact dermatitis (e.g., poison ivy), tuberculin skin test reactions, and some autoimmune diseases.
- Type IV Hypersensitivity (Delayed-Type Hypersensitivity):
WBC
• Function: Phagocytosis (engulfing and digesting pathogens).
• Role: They are the most abundant white blood cells and play a key role in the early stages of the immune response.
Neutrophils
WBC
• Types: T cells, B cells, and Natural Killer (NK) cells.
• Function: Adaptive immune response, including antibody production (B cells) and cell-mediated immunity (T cells).
Lymphocytes
WBC
• Function: Phagocytosis and antigen presentation.
• Role: They can migrate into tissues and differentiate into macrophages, which are large phagocytic cells.
Monocytes
WBC
• Function: Defense against parasites and involvement in allergic reactions.
• Role: They release substances that help modulate the immune response, particularly in allergic conditions.
Eosinophils
WBC
• Function: Release histamine and other substances involved in inflammation.
• Role: They play a role in the inflammatory response and are associated with allergic reactions.
Basophils
Occurs after second exposure to antigen
Anaphylactic reaction
Drug related anaphylaxis occurs after
2 minutes of drug administration
Myeloid reconstitution after bone marrow transplant
SARGAMOSTIN
Acts on estrogen in bones and lipids
RALOXIFENE
Cretinism in childrens is cause by which deficiency
IODINE
Contrindicated in breast feeding
COMBINED ESTROGEN
Inhibits folicular development and ovulation
ORAL CONTRACEPTIVES
Symptom of hypothyroidism
MYXOEDEMA
Test for human gonadotropins
WARNER LAMBENT TEST
Used for INFERTILITY
MENOTROPIN
Derived from theophylline, used in tx of PMS
PAMAPROM
AntiHTN with the most Ca ch blocking activity
VERAPAMIL
Contraindicated with digoxin, Ca, dysopyramide
VERAPAMIL
Triamterin diuretic class
K sparing diuretic
Toxicity of thiazied is due to decrease in
BLOOD VOLUME
Thiazides decrease tolerance of
GLUCOSE
A diuretic that is related to hyperurecimia, gout induction
THIAZIDE
Metabolic effects of diuretics
Thiazides/ loop- ALKALOSIS
K- sparing- ACIDOSIS
Electrolytes effect of diuretics
Thiazides: ⬇️Na, Cl, K, Mg; ⬆️ Ca
Loop: ⬇️Na, Cl, K, Mg, Ca
K-sparing: ⬇️ Na; ⬆️ K, Cl;
Diuretics that antagonizes insulin
THIAZIDES
Is added to methyldopa to relieve salt and water retention
THIAZIDES
The MOA of amiloride is similar to
TRIAMTERENE
Main source of pheripheral resistance
ARTERIOLES
Anti hypertensive of guantadine is inhibited by
AMITRYPTILINE
TCA and corticosteroids can cause
HTN
Starting dose of HCTZ
50mg
Site of action of spironolactone
DCT
Sensitivity to sunlight is caused by
Bendroflumethiazide
SE of Ca Ch blockers
CONSTIPATION AND EDEMA
SE of B blockers
HYPOGLYCEMIC EFFECT
DEC HDL
COLD EXTREMITIES
BRONCHOSPAMS
SE of amlodipine/ ACEi
PERIPHERAL EDEMA
PRURITUS
Safe diuretic with sulfonamide sensitivity
ETHACRYNIC AC
SPIRONOLACTON
Pallor or cyanosis of the fingers or toes
REYNAUD’s Disease
Tx of HTN crisis in hospital
DIAZOXIDE
Patients taking indapamide should take
K SUPPLEMEMENTS
Hydralazine causes tachycardia which is treated by
PROPRANOLOL
- First pass effect metabolism
Diuretics: Increase renal PG
LOOP DIURETICS
Initial drug therapy in HTN
THIAZIDES
Decreases Anti HTN effects of B blockers
INDOMETHACIN
Indapamide pts should take ___ and avoid____
K SUPPLEMENTS
ALCOHOL
Cough by ACEi should be treated with
GUAIFFENESIN
A vasoconstrictor that should be avoided in HTN
Carbenoxolone
is a drug that has been used historically for its anti-inflammatory and anti-ulcer properties.
HTN crisis caused by thyramine+ MAOi is treated with
ALPHA BLOCKERS
Hydralazine causes a syndrome resembling
SLE
Hydralazine cause anginal attack due to
CORONARY STEAL PHENOMENON
AntiHTN of choice for pts with renal insuffeciency
HYDRALAZINE
HTN pts on amitriptyline develops depression and tx should shift to
TRAZODONE
Is taken in the morning with food or milk
HCTZ
Combination of proranolol + ___ is not recommended
VERAPAMIL
Causes first dose effect: hypotension+ syncope
PRAZOSIN
Not used for initial treatment
A centrally acting alpha 2 agonist
GUANABENZ
Appropriate perindopril dose
4-8 mg
16mg max dose/day
Antihypertensive drug not to taken with tyramine rich food
PARGYLINE
Overdose of Na nitroprusside will cause
CNS poisoning
A vasodilator acting by direct muscolotropic and B agonistic activity
NYLIDRIN
(Buphenin)
Decreases after load
HYDRALAZINE
Is a arterrular/ venular dilator to be given by slow IV INFUSION
NA nitroprusside
Is similar to chlorthalidone
METOLAZONE
Increases effects of all antihypertensives
METHYLDOPA
Furosemide
Bumetanide
Ethacryninc acid
LOOP
CI with gout
Interacts with digoxin and lithium
HCTZ
Hypertensive of choice in depression
HCTZ
HYDRALAZINE
HCTZ in combination of this drug will decrease edema
PROPRANOLOL
CI with guanthidine and methyldopa
HALOPERIDOL
Gunathidine
Methyldopa
Clonidine
Causes
BRADYCARDIA
Hydralazine causes
REFLEX TACHYCARDIA
Guanthidine interacts withs
TCA
Guanthidine makes parasympathetic tone predominate thus cause
DIARRHEA
Venule dilator
NITROGLYCERINE (glyceryl trinitrate)
Diaxozide
Minoxidil
Hydralazine
Dilates?
Arteries
Duration of action of (t1/2)
Thiazide
Chlorthiazide
Chlorthalidone
Thiazide 15hrs
Chlorthiazide 3hrs
Chlorthalidone 50hrs
TCA, OC
clonidine withdrawal
Corticosteroids
Causes ___ HTN
IATROGENIC HTN
PRAZOCIN
NITROPRUSSIDE
KCL
Drugs that cannot be given by
IV BOLUS
HCTZ dose
0.5-1g
Dose of chlorthiazide
500-2000mg/day
Diaxozide is administered by
RAPID IV INJ
Hyperaldosteronemia is
COON’s
Should not be taken in HTN, bec of salt and water retention
CODEIN
INDOMETHACIN
Bumetanide SE
MYALGIA
Increase vascular permeability to release PG12 to relax smooth muscles
BRADYKININS
Bendrofluazide SE
PHOTOSENSITIVITY
Least lipid soluble B BLOCKER
ATENOLOL
Type of HTN that need immidiate medical attention
ARTERIAL HTN
AntiHTN that causes angina
HYDRALAZINE
Diuretic CI with amitryptiline
CHLORTHIAZIDE
Least reflex tachycardia among ACEi
AMLODIPINE
Methyldopa antagonizes
TCA
All ACEi are prodrugs except
CAPTOPRIL
LISINOPRIL
Acetazalomide cause systemic
ACIDOSIS
CI in asthma, renal artery stenosis, anti HTN class
ACEi
ACEi SE
HYPERKALEMIA
⬆️ CREATININE
Pulse is taken on
RADIAL ARTERY
Lisinopril max dose
20mg
Cough medicine for chesty cough
With history of HTN + hyperlipidemia
GUAIFENESIN
Drugs used in HTN/angina
CCB/ B blockers
