Pharmacology 1 Flashcards
The pharmacological effects of sumatriptan arise from its ability to:
Antagonise the actions of serotonin
Each of the following is a major determinant of myocardial oxygen demand EXCEPT
for:
Coronary blood flow
Antidote for belladona/
anticholinergic drugs overdose
PHYSOSTIGMINE
Beta 3 receptor agonist used im tx of overactive bladder
Mirabegron
MAOi used in tx of movement disorders
(clue benjamin/musa)
Tetrabenazine SE suicidal toughts
Reserpine also for paychiatric disorders
Selective Beta blockers without Intrinsic Sympathetic Activity
AMEBBN
Atenolol
Metoprolol
Esmolol
Bisoprolol
Nevibolol
Non selective beta blockers without ISA
(Clue Vee’s luggage)
PNSTT
Propranolol
Nadolol
Sotalol
Timolol
Tortalol
Succinylcholine should be taken with caution in patients taking
Phospholine
Nylidrin use
Vasodilator
Short acting DEPOLARIZING skeletal muscle reaxant
Suxamethonium
Skeletal muscle relaxant
Meprobamate
Levarterenol is also called
L-NOREPINEPHRINE
Dose of Atropine
0.2 - 2 mg
Cause hemodynamic alteration, initial tachycardia
ATROPINE
Similar action to atropine
BETHANECOL
Cholinergic agonist
Carbachol
COMT does not metabolize
ISOPRENALINE
CENTRALLY acting muscle relaxant
DANTROLENE
SE: seizure
PERIPHERALY acting skeletal muscle relaxants
BACLOFEN
ORPHENADRINE
CYCLOBENZAPRINE
Adrenaline is metabolized by
MAO
MAOi(pargyline) + Phenylephrine will cause
Elevated BP
ACH is
Choline ester
Damage of protein and peptides is due to
Deamination & oxidation
Tubocurarine MOA
Blocks postsynaptic ganglia
By competitive antagonism
Pts different response to suxamethonium is due to
Alternation in PSEUDOCHOLINESTERASE enzyme
Antiarrythmic causing pulmonary fibrosis, blood discrasias
Tocainide
The use of sotalol, it is necessary to monitor
CrCl
Sotalol causes
TDP
Quinidine causes which toxicity
Digoxin
Quinidine SE
Cinchonism
Drug of choice in tx of Atrioventricular reinterent tachycardia
Procainamide
Decreases toxicity of digoxin
Na Lactate
Increases QT interval
Ketokonazole
Cisapride
Phenothiazine
Quinolones
CHF patients requires dose adjustment of lidocaine because of
Impaired liver/metabolism
Of lidocaine
Do not treat ventricular arrythmia
Digitialis
Tx of atrial arrythmia
Amiodarone causes
Yellow deposits on cornea
Photosensitivity
Occular/sight problems
Adam stoke syndrome is cause by
Heart block
Ventricular contraction is
Systole
Mimics serotonin action
Sumatriptan
CI in CHF, angina & MAOi’s
Tocoloytic, oxytocic, uterine relaxation
Ritodrine
Prostaglandin is related to
Fatty acids
Tx of Reynolds disease
Pentoxyphylline
Serotonin antagonist in the brain
Methylsergide
Produces cardiac stimulation
Histamine
Used in tx of migrane, post partum hemorrhage
Ergotamine
Ergot alkaloids not taken sublingually
Ergometrin
Ergotamine Maleate
Antihistamin & anti 5HT (serotonin)
Cyproheptadine
2nd generation antihistamine not causing drowsiness
Astimazole
Used for patent ductus arteriosus
Alprostadil
Most common complication of MI
Ventricular fibrilation
Most specific lab investigation for MI
Cardiac troponin
A risk factor not related to MI
Rheumativ fever
Prescribe to pts with angina+ HTN
Na Nitroprusside
Ther dose of gyceryl trinitrate
0.5 - 1mg
Nitrogycerin increases which sexondary messenger
C-GMP
Finrinolytics(thrombolytics) are CI in
Duodenal ulcer pts
In MI it is necessary to monitor the level of
CPK
Increased level in CHF
The only antianginal inhalation
Amyl Nitrate
Perhexiline use
Prophylactic antianginal
Coronary vessel dilator
Decreases metabolism of perhexiline
Chlropromazine
Acebutolol
Betaxolol can worsen which cardiac condition
Aortic stenosis
CI in use of NGT
Alcohol
Sildenafil
Warfarin’s aftivity is due to
Optical isomer
Streptokinase dose
1.5MIU IV/ 60 mins
Streptokinase administration interval
6months
12 months if pt on antiplatelets
Antidote for heparin overdose
Protamine
Normal prothrombin time
12-15 secs
Normal APTT
(Activated partial thromboplastin time)
30-45 seconds
Heparin is obtained from
Beef lungs
Warfarin inhibits which enzyme
K epoxide reductase
Protamine dose limit in tx of heparin overdose
Not more than 100mg
In mild to moderate bleeding, The use of vit k in anti coagulant therapy will make it difficult to
Bridging therapy
To cover delayed action of warfarin use enoxaparin or heparin
Normal APTT
(Activated partial thromboplastin time)
Is used to measure
Heprin anticoagulation activity
Used to reverse hypo prothrombinemia
Fresh frozen plasma (FFP)
Anticoagulant DOC in pregnancy
Heparin
Clofibrate decrease platelet aggregation but increases (old fibrates)
HEPATIC CANCER
Used to tx of streptokinase overdose
Aminocaproic acid
Tranexamic acid
Used in tx of sever bleeding/hemorrhage
Vitamin K
In coagulation factors, thrombin and fibrin requires which ion
Calcium
LMW heprin are prefered As it can be given
IM
Heparin by IM cause HEMATOMA
Sulfazaline is metabolized to
5-amino salicylic acid
Used in tx of rheumatoid arthritis & ulcerative colitis (chron’s disease)
Sulfazalazine
Methotrexate and salicylate will cause
Bone marrow depression- anemia
Goeckerman treatment consists
Coal tar + UV
Dithranol used in psoriasis, therapeutic dose
0.1- 1%
Dithranol is stabilized in preparation of
ZnO paste + 2% salicilic acid