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Gastroenterology > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Antacid MOA

A

Neutralize gastric acid
Protect gastric mucosa
Promote angiogenesis in injured mucosa.
Suppress H. Pylori

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2
Q

H2 blocker types

A

Cimetidine (tagamet)
Ranitadine (zantac)
Fomotidine (pepcid)
Nizatidine (axid)

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3
Q

H2 blocker indications

A

PUD
GERD
Dyspepsia

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4
Q

H2 MOA

A

Inhibit acid secretion by blocking H2 receptors

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5
Q

H2 SE

A

Pancytopenia
Thrombocytopenia
Anemia
General myelosuppression

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6
Q

Sulcralfate (Carafate)

A

Sucrose octasulfate-aluminum hydroxide.
Prevents chemical induced mucosal damage
Heals chronic ulcers

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7
Q

Sulcralfate (Carafate) MOA

A

Stimulates angiogenesis and formation of tissue.

Should be given 30-60 minutes prior to meals

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8
Q

Proton pump inhibitors

A

End in prazole
Tx of all acid related disorders
Block acid secretion
Administer before first meal of day

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9
Q

PPE SE

A

Diarrhea
HA
Flatulence

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10
Q

Omeprazole has significant drug interaction with?

A

Plavix

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11
Q

Which PPI has the least amount of interactions?

A

Pantoprazole (protonix)

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12
Q

When should PPI’s be taken?

A

30-60 mins before first meal of day.

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13
Q

Bismuth

A

Suppresses H. pylori infection

not helpful in any other condition

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14
Q

Bismuth MOA

A

Inhibition of peptic activity bot not pepsin secretion

Promotes ulcer healing

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15
Q

Metaclopramide (Reglan)

A

First line for gastroparesis for no longer than 12 wks.

Improved gastric emptying but increasing contractions.

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16
Q

Metaclopramide (Reglan) MOA

A

Dopamine receptor antagonist
5-HT4 agonist
Weak 5-HT3 antagonist

17
Q

Metaclopramide (Reglan) SE

A

Anxiety, restlessness
depression, hyperprolactinemia
QT prolongation
Extrapyramidal SE

18
Q

Metaclopramide (Reglan) should be avoided when what drugs are being used?

A

Psych meds

Anything that messes with dopamine

Gastroenterology (14 decks)

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