pharmacology Flashcards

1
Q

what is used to categorise the risks of starting different methods of contraception and what are the categories

A

UKMEC 1-4
1 - no restriction in use
2 - benefits outweigh risk
3 - risks outweigh benefit
4 - unacceptable risk (method is contraindicated)

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2
Q

who should avoid the copper coil as a method of contraception

A

patients with wilsons disease

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3
Q

what is the common contraceptive of choice in epileptic patients and why

A

injection - COCP is less effective as anti-epileptics increase the metabolism of them

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4
Q

when does fertility return after giving birth

A

21 days

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5
Q

give an example of a combined oral contraceptive pill

A

microgynon, yasmin

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6
Q

MOA of combined oral contraceptive pill

A

prevents ovulation, thickens cervical mucus to block sperm, thins endometrial lining to prevent implantation

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7
Q

who is COCP contraindicated in

A

women with migraine with aura

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8
Q

what does the COCP give patients an increased risk of - and so what should be monitored

A

blood clots, stroke, MI
monitor BP and need smoking cessation

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9
Q

name some advantages of the COCP

A

regulates cycle, reduces pain and heavy periods, can improve acne, reduces risk of ovarian and endometrial cancer

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10
Q

what kind of contraception is the patch

A

combined

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11
Q

how does the contraceptive patch work logistically

A

patch applied to the skin, change once a week for 3 weeks and then have a week break

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12
Q

what kind of contraception is the vaginal ring and how is it used

A

combined
one worn for 3 weeks, then removed for 1 week and replaced with a new one

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13
Q

name some disadvantages of the vaginal ring

A

vaginal irritation and discharge
can cause discomfort during sex

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14
Q

give some names of progesterone only pills

A

cerazette, desogestrel

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15
Q

how is the progesterone pill taken

A

once a day at the same time
no break

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16
Q

what contraceptive should be avoided in patients who have had breast cancer

A

all hormonal - stick to condoms and copper coil instead

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17
Q

what contraceptive should be avoided in patients with cervical or endometrial cancer

A

IUS

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18
Q

when can you be started on a COCP after birth

A

after 6 weeks in breastfeeding women

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19
Q

when can a copper coil or IUS be started after birth

A

inserted either within 48hrs or after 4 weeks after birth
but not in between!!

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20
Q

when can the implant be started after birth

21
Q

when can the progesterone only pill be started after birth

22
Q

MOA of progesterone only pills

A

thickens cervical mucus, suppress ovulation

23
Q

what is a disadvantage of progesterone only pill

A

can cause irregular bleeding patterns

24
Q

what kind of contraception is the injection

A

progesterone only

25
administration of the contraceptive injection
intramuscular or subdermal administered every 3 months
26
what is a consideration needed for the contraceptive injection
fertility can take up to 1 year to return back to baseline after last injection
27
what kind of contraception is the implant
progesterone only
28
give a name of a contraceptive implant
nexplanon
29
what are some side effects of the contraceptive implant
irregular bleeding patterns headaches + breast tenderness
30
what kind of contraception is the IUS
progesterone only
31
give an example of an IUS
mirena
32
name some risks associated with IUS
uterine perforation and risk of expulsion
33
what condition can an IUS be particularly useful in
endometriosis
34
how does the copper coil work
copper is toxic to sperm so stops them fertilising the egg
35
aside from contraception - what is another benefit of using barrier contraception
helps prevent STIs
36
what is the mechanism of action of HAART and what is it indicated in
HIV - antiretrovirals
37
when should contraceptive pills be started in the cycle
ideally on day 1 of period
38
how long does it take contraceptive pills to be effective - both COCP and progesterone only
progesterone only - 48 hours COCP - 7 days
39
what is the aim of treatment in HIV
achieve a normal CD4 count and undetectable viral load
40
why should NSAIDs particularly be avoided in the 3rd trimester of pregnancy
can cause premature closure of the ductus arteriosus + also delay labour
41
what is the most commonly used beta blocker in pregnancy
labetalol
42
what are some complications associated with using ACEi or ARBs during pregnancy
oligohydramnios miscarriage/foetal death hypocalvaria renal failure and hypotension in neonate
43
what is hypocalvaria
incomplete formation of the skull bones
44
why is sodium valproate contraindicated in pregnancy
can cause neural tube defects and developmental delay
45
what anomaly is the use of lithium in first trimester associated with - and what is it
ebstein's anomaly congenital heart disease - problem with tricuspid valve
46
which derm drug is contraindicated during pregnancy
isotretinoin
47
how can pregnancy affect pharmacokinetics of a drug
absorption affected by morning sickness increased plasma volume - Vd increases increased liver metabolism increased GFR - increased excretion
48
what is the period of greatest teratogenic risk during pregnancy
4th-11th week
49
med used to treat N+V during pregnancy
cyclizine