Pharmacology Flashcards
Formula for oral maintenance dose.
Maintenance = peak conc * clearance / oral bioavailability
Which drugs follow zero order kinetics?
Peas and wheats
P - phenytoin W - warfarin H - heparin E - ethanol A - aspirin T - theophylline S - salicylates
Features of an anticholinergic toxidrome.
Blind as a bat Mad as a hatter Hot as a desert Dry as a bone Red as a beet Dilated pupils Tachycardia
Cholinergic toxidrome
Pin point pupils Lacrimation Diarrhoea Bradycardia Rhinorrhea Salivation Urination Vomiting Muscle fasciculation
How do you differentiate serotonin syndrome and NMS?
Serotonin Syndrome - hyperreflexia and clonus
NMS - lead pipe rigidity and hyporeflexia
Mechanism of Pegvisomant
Growth hormone receptor antagonist
Mechanism of basiliximab
Interleukin 2 inhibitor
Mechanism and use of anakinra.
Interleukin 1 inhibitor
Uses:
FMF, Gout, Rheumatoid arthritis, recurrent pericarditis
What is the rough onset of drug hypersensitivity?
2-4 weeks
What are the contraindications to TNF alpha therapy?
Septic arthritis <12 months Congestive heart failure Demyelination disease Malignancy within 10 years Active infection Untreated tuberculosis Recurrent chest infections
What is the mechanism of colchicine?
Inhibits B tubulin polymerisation preventing neutrophil migration.
What is the mechanism of varenicline?
Partial nicotine receptor agonist
What is the major function of COX1
Gastrointestinal protection
What is the major function of COX2?
Cardiovascular protection.
What does rifampicin do to CYP450?
Inducer
