Immunology Flashcards
Diagnostic criteria for Takayasu arteritis.
Requires 3 of 6 for diagnosis
- age <40
- claudication of extremity
- decreased pulsation of brachial artery
- bruit over subclavian or abdo aorta
- arteriographic narrowing of aorta or large branches
- Difference of BP of 10mmhg between each arm
Giant cell arteritis diagnostic criteria.
Needs 3 of 5 criteria
- age >50 years
- localised new onset headache
- tenderness or decreased pulse of temporal artery
- ESR >50
- biopsy revealing necrotising arteritis with giant cells
Diagnostic criteria for churg Strauss syndrome
4 of 6 criteria required
- asthma
- > 10% eosinophils in blood
- mono or polyneuropathy
- migratory or transient pulmonary opacities
- paranasal sinus abnormality
- biopsy showing eosinophil accumulation in extravascular areas
What is the purpose of somatic hypermutation of B cells?
Selection of high affinity B cells
What cell does FOXP3 promote?
T regulatory cells
What are the clinical characteristics of adult onset stills disease?
Daily fever Cutaneous evanescent salmon pink eruption Arthritis Leukocytosis (neutrophils) Ferritin elevation
What is the mechanism of canakinumab?
IL 1 beta inhibitor
What is the management of a pregnant female with APLS and prior thrombosis?
Therapeutic clexane and aspirin
What is the management of a pregnant female with APLS and prior miscarriage without thrombosis?
Clexane prophylaxis
Aspirin regularly
What is the most common infective association of PAN?
Hepatitis B
What organ system is classically spared by PAN?
Lungs
What are the histological findings of PAN?
Segmental transmural necrosis of medium size arteries.
What is the management of familial Mediterranean fever?
- Colchicine
2. IL 1 inhibitors
What is the mechanism of icatibant?
Bradykinin inhibitor
Mechanism of imiquimod
Toll like receptor 7 agonist
