Pharmacology Flashcards
Which recreational drug is a risk factor for MI?
Cocaine
For which cancer types does the COCP have a protective effect?
Ovarian, endometrial, colorectal
Which vitamin is folate?
B9
Which vitamin is thiamine?
B1
What rheumatic disease contraindicates COCP?
SLE with antiphospholipid antibodies
Absorption of iron?
10% of oral dose
Malaria treatment in pregnancy?
Artesunate
What is the mechanism of action of ulipristal acetate?
Selective progesterone modulator with partial antagonist effect
SE of therapy with ulipristal acetate?
Progesterone receptor modulator associated endometrial change
HRT benefits
Control of menopausal symptoms
Maintenance of BMD
Reduced risk CAD
Reduced risk Alzheimer’s when estrogen started early
Reduced risk colorectal cancer
Reduced risk T2DM
Minimum duration of oral progesterone to provide endometrial protection?
12-14 days
Cyclizine drug class?
H1 antagonist
Drug to reduce fetal transmission of toxoplasmosis?
Spiramycin
Which drug inhibits breakdown of cAMP thereby promoting smooth muscle relaxation?
Reduction of Fe3+ to Fe2+ is inhibited by?
Tea
Reduction of Fe3+ to Fe2+ is inhibited by?
Tea
How many hours pre-delivery can pethidine cause neonatal respiratory depression?
2h
What kind of drug is misoprostol?
Prostaglandin E1 analog
What kind of drug is carboprost (Hemabate)?
Prostaglandin F2 alpha analog
COCP effect on hormone profile?
Lower FSH, LH, E2
No change AMH
What is the prodrug of 6-mercaptopurine?
Azathioprine
Toxoplasmosis treatment?
Spiramycin if no fetal infection
Pyrimethamine/sulphadiazine/folinic acid if fetal infection
Cabergoline and bromocriptine are agonists of which receptor?
D2
Methyl-dopa mechanism of action?
Post synaptic A2 adrenergic receptor agonist reducing central sympathetic outflow
Labetalol mechanism of action?
Mixed alpha/beta adrenergic antagonist (beta > alpha)
Hydralazine mechanism of action?
Direct acting smooth muscle relaxant
Increases cGMP levels, decreasing phosphorylation of smooth muscle myosin light chains —> smooth muscle relaxation
Endothelium provides NO
