Pharmacology Flashcards

1
Q

CP450 inducers

A

Reduce conc of drugs metabolised by cP450 system.
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Sulphonylureas- eg gliclazide
Carbamazepine
Rifampicin
Alcohol- chronic consumption
Phenytoin
Griseofulvin
Phenobarbitol
St Johns Wort

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2
Q

CP450 Inhibitors

A

Increase concentration of drugs metabolised by cP450 system
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Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluoxetine/Fluconazole
Alcohol- binge
Chloramphenicol
Erythromycin
Sulfonamides
Ciprofloxacin
Omeprazole
Metronidazole

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3
Q

Drugs that are metabolised by the CP450 system

A

COWPATS
Ciclosporins/Citalopram
Omeprazole
Warfarin
Phenytoin
Acetylcholinesterase inhibitors (dementia tx)
Theophylline
Statins

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