Pharmacology

Question 1

Side effects of ACEi

Answer 1

Cough (15% of people)
Angioedma (can occur up to 1yr later)
Hyperkalaemia
First dose hypotension

Question 2

Monitoring for ACEi

Answer 2

UEC checked before treatment initiated and after changing dose
-Accept creatinine up to 30% baseline and K up to 5.5

Question 3

Which SSRI causes most significant QT prolongation?

Answer 3

Citalopram

Question 4

Which SSRI to be used after MI?

Answer 4

Sertraline

Question 5

What drugs interact with SSRIs?

Answer 5

Warfarin and heparin
MAOI (increase serotonin syndrome)
triptans
NSAID- give PPI to cover

Question 6

SSRIs cause what SE in baby in;
First trimester
Third Trimester

What dose paroxetine specifically cause in baby

Answer 6

Congenital Heart defects in first
Persistent pulmonary hypertension in third trimester

Paroxetine increases risks of congenital malformations

Question 7

Side effect os spironolactone?

Answer 7

Hyperkalaemia
Gynaecomastia

Potassium sparing diuretic

Question 8

What should you never co-prescribe with methotrexate?

Answer 8

Trimethoprim-Sulfa (Ci-trimoxazole)
Causes myelosuppression