Pharmacology

Question 1

What is the code dose of epinephrine (in ml/kg) for IV? For ETT?

How soon can you give IV epi after ETT epi?

Answer 1

For 1:10,000 concentration

IV/IO: 0.2 ml/kg

ETT: 1 ml/kg (range 0.5 ml-1 ml/kg)

You can give IV epi immediately after giving ETT epi

Question 2

Why won’t sodium acetate work to correct acidosis in a patient with liver failure?

Answer 2

Acetate requires the Kreb cycle for conversion to bicarb

Question 3

How long does hydrocortisone stay in a neonates system?

Answer 3

For most it is in the system for 24-48 hours after the last dose. However for low birth weight infants it may be in system up to a week

Question 4

What is the typical cryoprecipitate dose? What is it given for?

Answer 4

10 ml/kg over 1 hour (remember C-F-P-Pr: cryo, FFP, platelet, PRBC where cryo is 10/kg, FFP and platelets are 10-15/kg, PRBCs are 15/kg)

Given for fibrinogen <100

Question 5

What is the typical FFP dose? What is it given for?

Answer 5

10-15 ml/kg over 1 hour (remember C-F-P-Pr: cryo, FFP, platelet, PRBC where cryo is 10/kg, FFP and platelets are 10-15/kg, PRBCs are 15/kg)

Given for PT>19 or INR >2 if unstable/>2.5 stable patients or for PTT >55

Question 6

What is the typical platelet dose?

Answer 6

10-15 ml/kg over 1 hour (remember C-F-P-Pr: cryo, FFP, platelet, PRBC where cryo is 10/kg, FFP and platelets are 10-15/kg, PRBCs are 15/kg)

Question 7

Morphine should not be given if there are concerns about ———- function.

Answer 7

Liver

Functioning liver is required for morphine metabolism. Consider fentanyl instead if in liver failure

Question 8

What is the dose of stress hydrocortisone?

Answer 8

1 mg/kg/dose Q8