Pharmacology

Question 1

Clozapine

Answer 1

Atypical antipsychotics
Only used if schizophrenia not controlled with two or more antipsychotics for at least 6-8 weeks

Adverse effects:

1. Agranulocytosis, neutropenia(FBC monitoring)
2. Reduce seizure threshold( like ciprofloxacin)
3. Myocarditis(baseline ECG)
4. Increased saliva production

Question 2

Amiodarone

Answer 2

Class 3 antiarrythmic( inhibiting K channel)

Monitoring: TFT,LFT, U&E and CXR at Baseline
TFT and LFT every 6 months

Adverse effects: 
Thyroid problems (hence TFT)
Pulmonary fibrosis(hence CXR)
Liver fibrosis (hence LFT)
Corneal deposits
Peripheral neuropathy
Photo sensitivity
Slate grey appearance (skin looks grey)
Bradycardia 
Long QT

Question 3

Enzyme CYP 450 inhibitors

SICKFACES.COM

Answer 3

Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol(binge)
Chloramphenicol 
Erythromycin
Sulphonamide
Ciprofloxacin
Omeprazole
Metronidazole

Question 4

CYP 450 inducers

CRAP GPS

Answer 4

Carbamazepine
Rifampicin
Alcohol(chronic)
Phenytoin
Griseofulvin
Phenobarbital
Sulphonylurea

ALSO St John’s wort so it reduces effectiveness of warfarin, COCP, cyclosporin etc

Question 5

Tamoxifen side effects

Answer 5

1. ++endometrial cancer
2. VTE risk +++
3. Fatty liver and hypertriglyceridaemia