Pharmacology Flashcards
Term:
Pharmacy
Pharmacology
Therapeutics
handling on drugs
science of drugs
medical use of drugs
Pharmacodynamics definition
what the drug does to an organism
all actions of drug, incl side effects
Pharmacokinetics
What the organism does to the drug
absorption, distribution, metabolism, excretion
Drugs are chemicals which bind to …….. in ……. (almost always proteins) and mimic, …….. or ……. the action of endogenous ……… or ………..
molecules cells stimulate block molecules processes
Chemotherapeutic drugs are agents which act against ……… ……… or cancer cells by exploiting ……… differences between the ……… and ……..
infectious microorganisms
biochemical
host
target
binding sites are mainly found on …….,, ……….. molecules, … channels and ……..
enzymes
carrier
ion
receptors
receptors are …….. which messenger …….. to a …….. site
proteins
molecules
binding
once binding site is occupied the receptor changes ……. and this initiates ….. which change the …….. of the cell
shape
processes
function
The affinity of a drug for its receptor is the conc of drug required to occupy ..% of the ……… at ………… High affinity means low …
50%
receptors
equilibrium
Kd
The efficacy of a drug relates to its ability to ……… the ……. so a ……….. is produced
activate
receptor
response
What is a agonist
drugs which activate receptors
What is a antagonist
drugs which bind to receptors but don’t activate them
Affinity and Efficacy for :
Full agonist
Partial agonist
Antagonists
A E
Y high
Y low
Y no
Four classes of receptors
Ligand gated ions (ms)
G protein coupled (seconds)
Kinase linked (hours)
Transcription factors (hours)
A “potent” drug can be potent because of its …… ……. to its …….. or to its ……. …….. or to its …….. ………. …….. in the body
high affinity
receptor
low efficacy
slow metabolic breakdown
