amino acids and protein Flashcards
Amino acids are ………. blocks of ………..
building
protein
Amino acids are ……… soluble and ………. Charged at physiological …. Each amino acid differs in the properties of its …….. …….
water soluble
electrically charged
pH
side chain
In polypeptides, amino acids are linked by ……. …….. Side chains are ….. involved in peptide bonding
peptide bonds
NOT
Direction of polypeptides, first amino acid has ….. group ..terminal end. Last amino acid has …. Group ..terminal end
NH3+
N-
COO-
C-
hydrolysis only ………. and ………..
digestion
lyosome
The protein primary structure is a ……… of amino acids in a ……
sequence
peptide
The secondary structure is ……… or ……… of peptide chain (a-helix/b-pleated sheet)
folding
coiling
The tertiary structure peptide chain ……. …….. ………
fold upon itself
The quaternary structure the folded peptide …… …… ………
chains going together
a-helix is formed by …… in the same ……. chain. regular ……….. helix. … residues. …….. on the outside
H-bonds polypeptide right-handed 3.6 R groups
B-pleated sheets …….. ……. chains. ……….. between peptide chains holds strands together
liner peptide
H-bonding
Two types of B-sheet structures
antiparallel - widespread in globular proteins
parallel - arrows point to C terminus
Haemoglobin has ..% of its structure as a-helix
60
covalent bond that stabilises the protein structure
disulphide bridges
non-covalent bonds that stabilise the protein structure
hydrogen bonds
electrostatic interactions
van-der Waals forces
hydrophobic effect