Pharmacology (1-24) Flashcards
what does rINN stand for
recognised international non-prprietary name
what does BAN stand for
British Approved Name
what does USAN stand for
United States Approved Name
this determines what the body does to the drug (Absorption, Distrbution, Metabolism, Excretion)
pharmacokinetics
name the 4 parts of pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Excretion
this is defined as what the drug does to the body / the relationship to drug concentration at the effect site
pharmacodynamics
name the pharmacokinetic model
helps understanding but is not directly relevant for clinical practice
one-compartment model
name the pharmacokinetic model
describes movement between compartments; drug is only removed from central compartment
two-compartment model
name the pharmacokinetic model
most commonly used to describe clinical scenarios
three-compartment model
name the pharmacokinetic model
drug is eliminated from the body, elimination occurs from central compartment
open model
name the pharmacokinetic model
drug is recirculated / drug is released into GIT via bile and then reabsorbed into plasma (enterohepatic recirculation)
closed model
reaction order?
rate at which drug concentration changes is constant and independent of drug concentration; rate of elimination is constant
zero order kinetics: 𝚫C/𝚫t = -K0
reaction order?
rate of drug elimination changes and is proportional to drug concentration; drug concentration decays exponentially; applies to most commonly used drugs
first order kinetics: 𝚫C/𝚫t = -KC
name 4 pH environments that may lead to ion trapping effect with drugs
- gastric pH
- fetal pH
- milk pH
- urine pH
what is the Henderson Hasselbach equation for acids
pH - pKa = log(ionized/nonionized)
what is the Henderson Hasselbach equation for bases
pH - pKa = log (nonionized/ionized)
how to find the pKa of a drug
pH at which 50% of the drug is ionized
this is the passage of a drug from site of administration to blood stream; influenced by solubility, physiochemical properties, site of administration, and bioavailability
absorption
name the 3 types of parenteral administration
- intravenous
- intramuscular
- subcutaneous
name the route of administration
most rapid onset of action, rate of administration usually slow
intravenous
name the route of administration
bypasses GIT, achieves sytemic levels more rapidly, advantageous when animal is inappetant or vomiting
parenteral
name the route of administration
often the only option for owners, influenced by speed of gastric emptying and presence of food
oral
this refers to the removal of a percentage of the drug as it passes through the liver via the portal vein before it reaches the systemic circulation and effect site
first pass effect
what effect does vasoconstriction have on absorption of agent from a site
reduces it